Development and application of an in-cell cleanup pressurized liquid extraction with ultra-high-performance liquid chromatography-tandem mass spectrometry to detect prohibited antiviral agents sensitively in livestock and poultry feces
文献类型： 外文期刊
作者： Wu, Huizhen 1 ; Wang, Jianmei 2 ; Yang, Hua 2 ; Li, Guoqin 3 ; Zeng, Yinhuan 2 ; Xia, Wei 1 ; Li, Zuguang 1 ; Qian, Mingr 1 ;
作者机构： 1.Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Qual & Standard Agroprod, MOA Key Lab Pesticide Residue Detect, Hangzhou 310021, Zhejiang, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Antiviral agents;Pressurized liquid extraction;Livestock and poultry feces
期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.759； 五年影响因子：4.302 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： An in-cell cleanup pressurized liquid extraction was developed to analyze prohibited antiviral agents in livestock and poultry feces. Extraction and cleanup were integrated into one step. The extraction was performed using methanol-acetonitrile (1:1, v/v) with 0.5% glacial acetic acid at 90 degrees C, and 0.75 g of PSA was used as the adsorbent during the extraction procedure. Under optimal conditions, the average recoveries for 11 antiviral drugs were 71.5-112.5% at three spiked levels (20, 40, and 100 mu g kg(-1)). The detection limits and detection quantitations of the analysis method for the eleven antiviral drugs were 0.6-1.4 and 1.4-4.7 mu g kg(-1), respectively. Finally, the method was applied to analyze amantadine, oseltamivir and its metabolites oseltamivir acid in duck feces based on an experiment of an oral dose of two antiviral drugs in duck. The amantadine, oseltamivir and oseltamivir acid can be detected in feces within approximately four weeks after amantadine and oseltamivir were orally administered. The results indicate that the residue analysis in feces is a noninvasive method to monitor inhibited antiviral agents efficiently in livestock and poultry breeding. (C) 2017 Published by Elsevier B.V.
- 相关文献
作者其他论文 更多>>
-
Co-exposure to sodium hypochlorite and cadmium induced locomotor behavior disorder by influencing neurotransmitter secretion and cardiac function in larval zebrafish
作者：Ma, Lingyan;Yang, Hua;Xiao, Xingning;Chen, Qu;Lv, Wentao;Wang, Wen;Xiao, Yingping;Xu, Ting;Jin, Yuanxiang
关键词：Sodium hypochlorite; Cadmium; Zebrafish larvae; Oxidative stress; Neurotransmitters; Myocardial contraction
-
Stereoselective bioaccumulation and degradation of chiral pesticide hexythiazox in earthworm-soil microcosm
作者：Song, Ningying;Zhuang, Jiyang;Song, Ningying;Zhuang, Jiyang;Wu, Huizhen;Sun, Nabo;Zhang, Hu;Qian, Mingrong
关键词：Enantioselectivity; Elimination; Earthworm; Hexythiazox; Stereoselective bioaccumulation
-
Simulated gastrointestinal digestion of walnut protein yields anti-inflammatory peptides
作者：Xia, Wei;Fang, Xiangjun;Liu, Ruiling;Wu, Weijie;Gao, Haiyan;Yang, Hailong;Jin, Long;Deng, Yangyong;Gao, Junlong;Gao, Yuan;Wang, Li-Shu;Wang, Li-Shu
关键词：Walnut protein; Simulated digestion; Metabolic changes; Molecular docking; Inflammation; Cell experimental verification
-
Insights into microbial contamination and antibiotic resistome traits in pork wholesale market: An evaluation of the disinfection effect of sodium hypochlorite
作者：Xiao, Xingning;He, Miao;Ma, Lingyan;Lv, Wentao;Yang, Hua;Xiao, Yingping;Wang, Wen;He, Miao;Huang, Kang;Li, Yanbin;Zou, Likou;Xiao, Yingping;Wang, Wen;Zou, Likou
关键词：Pork wholesale market; NaClO; Chlorine tolerance; Metagenomics; Antimicrobial resistance
-
Effects of coated sodium butyrate on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and intestinal microbiota of broiler chickens
作者：Hou, Jinwang;Lu, Lizhi;Lian, Lina;Tian, Yong;Zeng, Tao;Chen, Li;Xu, Wenwu;Gu, Tiantian;Li, Guoqin;Ma, Yanfen;Li, Sisi;Liu, Xin
关键词：coated sodium butyrate; growth performance; serum antioxidant; gut microbes; yellow-feathered broiler
-
Tracking investigation of archaeal composition and methanogenesis function from parental to offspring pigs
作者：Chen, Qu;Lyu, Wentao;Pan, Chenglin;Ma, Lingyan;Sun, Yue;Yang, Hua;Wang, Wen;Xiao, Yingping
关键词：Swine gut archaea; Metagenomics; Methanogenesis function; Longitudinal study
-
Revealing microbial community composition and disinfection efficacy evaluation in wholesale pork markets through 16S rDNA sequencing
作者：He, Miao;Lan, Hangzhen;He, Miao;Ma, Lingyan;Lv, Wentao;Xiao, Yingping;Yang, Hua;Wang, Wen;Xiao, Xingning;Wang, Xiaofan;Zhao, Jiangchao;Wang, Wen;Xiao, Xingning
关键词：Pork; wholesaler; 16S rDNA amplicon sequencing; bacterial contamination; NaClO disinfection
