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Analysis of Melamine in Milk Powder by CNT-MIP with Matrix Solid Phase Dispersion and LC-MS/MS

文献类型： 外文期刊

作者： Wang, Yu 1 ; Gao, Lei 2 ; Qin, Dongli 2 ; Chen, Ligang 1 ;

作者机构： 1.Northeast Forestry Univ, Dept Chem, Coll Sci, 26 Hexing Rd, Harbin 150040, Peoples R China

2.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, 232 Hesong St, Harbin 150070, Peoples R China

关键词： Carbon nanotube;Molecularly imprinted polymers;Matrix solid phase dispersion;Melamine;LC-MS/MS

期刊名称：FOOD ANALYTICAL METHODS （ 影响因子：3.366； 五年影响因子：3.07 ）

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收录情况： SCI

摘要： In this work, a simple and selective method based on matrix solid phase dispersion (MSPD) using molecularly imprinted polymers (MIPs) as sorbents was successfully developed for the determination of melamine (MEL) in milk powder. The MIPs have been prepared by surface imprinted polymerization method using carbon nanotube (CNT) as support, MEL as template molecule, gamma-aminopropyltriethoxysilane as functional monomer, and tetraethyl orthosilicate as cross-linking agent. The MIPs were characterized by Fourier transform infrared spectrometer and scanning electron microscopy. At the same time, the adsorption isotherm, dynamic adsorption, and selective adsorption of MIPs to MEL were also studied. The prepared MIPs were used as dispersant of MSPD to extraction and separate MEL in milk powder. We optimized the extraction conditions as follows: the ratio of MIPs to sample was 2:3; the dispersion time was 10 min; washing solvent was 2.0 mL acetonitrile; and elution solvent was 4.0 mL ammonium methanol (5:95, v/v). Once the MSPD process was completed, the MEL extracted from milk powder was determined by LC-MS/MS. Under the optimal conditions, the limit of detection of MEL was 0.2 ng g(-1). The relative standard deviations of intra-day and inter-day were obtained in the range of 0.4 +/- 5.1 %. The satisfied recoveries of MEL were 92.5 +/- 97.2 %. The MIP-MSPD method has some advantages, such as higher selectivity, lower cost of preparation, less time consuming and organic solvent consumption, simpler sample pretreatment procedure, and higher extraction recovery compared with those existing methods which were used for determination of MEL.

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