Intracellular Staphylococcus aureus Control by Virulent Bacteriophages within MAC-T Bovine Mammary Epithelial Cells
文献类型： 外文期刊
作者： Zhang, Lili 1 ; Sun, Lichang 1 ; Wei, Ruicheng 1 ; Gao, Qiang 1 ; He, Tao 2 ; Xu, Cunfa; Liu, Xianjin; Wang, Ran;
作者机构： 1.Jiangsu Acad Agr Sci, Key Lab Control Technol & Stand Agroprod Safety &, Key Lab Food Qual & Safety Jiangsu Prov,Minist Ag, State Key Lab Breeding Base,Inst Food Qual & Safe, Nanjing, Jiangsu, Peoples R China
2.Jiangsu Acad Agr Sci, Key Lab Control Technol & Stand Agroprod Safety &, Key Lab Food Qual & Safety Jiangsu Prov,Minist Ag, State Key Lab Breeding Base,Inst Food Qual & Safe, Nanjing,
关键词： MAC-T cells;Staphylococcus aureus;bacteriophages
期刊名称：ANTIMICROBIAL AGENTS AND CHEMOTHERAPY （ 影响因子：5.191； 五年影响因子：5.346 ）
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收录情况： SCI
摘要： Bacteriophages (phages) are known to effectively kill extracellular multiplying bacteria. The present study demonstrated that phages penetrated bovine mammary epithelial cells and cleared intracellular Staphylococcus aureus in a timedependent manner. In particular, phage vB_SauM_JS25 reached the nucleus within 3 h postincubation. The phages had an endocytotic efficiency of 12%. This ability to kill intracellular host bacteria suggests the utility of phage-based therapies and may protect patients from recurrent infection and treatment failure.
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