文献类型： 外文期刊
作者： Huo, Shi-Xia 1 ; Wang, Qiong 2 ; Liu, Xin-Min 1 ; Ge, Chun-Hui 4 ; Gao, Li 1 ; Peng, Xiao-Ming 1 ; Yan, Ming 1 ;
作者机构： 1.Xinjiang Inst Tradit Uyghur Med, Prescript Lab Xinjiang Tradit Uyghur Med, Urumqi 830049, Peoples R China
2.Southwest Med Univ, Sch Pharm, Preclin Med Res Ctr, Luzhou 646000, Peoples R China
3.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
4.Xinjiang Acad Agr Sci, Inst Soil & Fertilizer & Agr Water Conservat, Urumqi 830011, Peoples R China
关键词： butin;vitiligo;mouse;hydroquinone
期刊名称：PHYTOTHERAPY RESEARCH （ 影响因子：5.878； 五年影响因子：5.286 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Vernonia anthelmintica (L.) Willd has been traditionally used in the treatment of vitiligo in Uyghur medicine. This study used butin, the main component of V.anthelmintica, to study the influence on hydroquinone-induced vitiligo in mice. The animals were randomly divided into six groups: control, model, 8-methoxypsoralen (8-MOP, 4.25mg/kg), and butin (0.425, 4.25, and 42.5mg/kg) groups. The number of melanin-containing hair follicles, basal layer melanocytes, melanin-containing epidermal cells, the expression of tyrosinase (TYR) and tyrosinase-related protein-1 (TRP-1), the malondialdehyde (MDA), and cholinesterase (CHE) activity in serum were measured. Our results indicated that compared with the model group, the melanin-containing hair follicles, the expression of TYR and TRP-1 increased, the activity of CHE decreased after treatment with 8-MOP and all doses of butin (p<0.05, p<0.01), the basal layer melanocytes and melanin-containing epidermal cells increased significantly after treatment with butin 4.25 and 42.5mg/kg (p<0.05, p<0.01), and the MDA activity decreased after using butin 4.25 and 42.5mg/kg and 8-MOP (p<0.05, p<0.01). Our results support the use of butin on vitiligo, and its possible mechanisms may be related to increase the TYR and TRP-1 protein expression and decrease the activity of MDA and CHE in hydroquinone-induced vitiligo model in mice. Copyright (c) 2017 John Wiley & Sons, Ltd.
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