Activity of cefquinome against extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in neutropenic mouse thigh model
文献类型： 外文期刊
作者： Shan, Q. 1 ; Wang, J. 2 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Key Lab Trop & Subtrop Fishery Resource Applicat, Guangzhou 510380, Guangdong, Peoples R China
2.Guangdong Lab Anim Monitoring Inst, Guangdong Prov Key Lab Lab Anim, Guangzhou, Guangdong, Peoples R China
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Increasing prevalence of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae (K.pneumoniae) is of clinical concern. The objective of our study was to examine the invivo activity of cefquinome against ESBL-producing K.pneumoniae strain using a neutropenic mouse thigh infection model. Cefquinome kinetics and protein binding in infected neutropenic mice were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Dose-fractionation studies over a 24-h dose range of 2.5-320 mg/kg were administered every 3, 6, 12, or 24 h. The percentage of the dosing interval that the free-drug serum levels exceed the MIC (%fT > MIC) was the PK-PD index that best correlated with cefquinome efficacy (R-2 = 86%). Using a sigmoid E-max model, the magnitudes of %fT > MIC producing net bacterial stasis, a 1-log(10) kill and a 2-log(10) kill over 24 h, were estimated to be 20.07%, 29.57%, and 55.12%, respectively. These studies suggest that optimal cefquinome PK/PD targets are not achieved in pigs, sheep, and cattle at current recommended doses (1 similar to 2mg/kg). Further studies with higher doses in the target species are needed to ensure therapeutic concentration, if cefquinome is used for treatment of K.pneumoniae infection.
- 相关文献
作者其他论文 更多>>
-
Validation of growth-related quantitative trait loci markers in different Exopalaemon carinicauda families for marker-assisted selection
作者：Wang, J.;Li, M.;Qin, Z.;Li, J.;Wang, J.;Qin, Z.;Li, J.;Li, M.
关键词：general linear model; mixed linear models; molecular markers; quantitative trait loci validation
-
Pharmacokinetics of cefquinome in crucian carp (Carassius auratus gibelio) after oral, intramuscular, intraperitoneal, and bath administration
作者：Shan, Q.;Ma, L.;Yin, Y.;Liu, S.;Li, L.;Zheng, G.;Shan, Q.;Ma, L.;Yin, Y.;Liu, S.;Li, L.;Zheng, G.;Wang, J.;Yang, F.
关键词：cefquinome; compartment model; Crucian carp; HPLC; pharmacokinetics
-
Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)
作者：Shan, Q.;Fan, J.;Zhu, X.;Yin, Y.;Zheng, G.;Wang, J.
关键词：ciprofloxacin; crucian carp; enrofloxacin; pharmacokinetic
-
Characterization, molecular cloning, and expression analysis of Ecsit in the spinyhead croaker, Collichthys lucidus
作者：Song, W.;Jiang, K. J.;Zhang, F. Y.;Wang, J.;Ma, L. B.
关键词：Collichthys lucidus;Ecsit;Quantitative real-time PCR;Tissue expression
-
Characterization and expression analysis of the prophenoloxidase activating factor from the mud crab Scylla paramamosain
作者：Wang, J.;Jiang, K. J.;Zhang, F. Y.;Song, W.;Zhao, M.;Wei, H. Q.;Meng, Y. Y.;Ma, L. B.;Wang, J.;Zhao, M.;Wei, H. Q.;Meng, Y. Y.
关键词：Scylla paramamosain;Quantitative real-time PCR;Prophenoloxidase activating factor
-
Characterization of hemocyanin from the mud crab Scylla paramamosain and its expression analysis in different tissues, at various stages, and under Vibrio parahaemolyticus infection
作者：Wang, J.;Zhang, F. Y.;Song, W.;Hu, J. H.;Zhao, M.;Jiang, K. J.;Ma, L. B.;Wang, J.;Hu, J. H.;Zhao, M.;Fang, Y. B.
关键词：Scylla paramamosain;Hemocyanin;Quantitative real-time PCR
-
Molecular characterization of thioredoxin-1 and thioredoxin reductase activity in mud crab Scylla paramamosain
作者：Hu, J. H.;Zhang, F. Y.;Jiang, K. J.;Fang, Y. B.;Wang, J.;Zhao, M.;Qiao, Z. G.;Ma, L. B.;Hu, J. H.;Fang, Y. B.;Wang, J.;Zhao, M.
关键词：Scylla paramarnosain;Thioredoxin reductasc activity;Thiorcdoxin reductase;Thioredoxin-1 gene;Tissue expression;Quantitative real-time polymerase chain reaction
