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Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice

文献类型： 外文期刊

作者： Li, Xiaopeng 1 ; Sui, Yong 2 ; Wu, Qian 3 ; Xie, Bijun 1 ; Sun, Zhida 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China

2.Hubei Acad Agr Sci, Inst Farm Prod Proc & Nucl Agr Technol, Wuhan 430064, Peoples R China

3.Hubei Univ Technol, Hubei Collaborat Innovat Ctr Ind Fermentat, Wuhan 430068, Peoples R China

关键词： lotus seed oligomeric procyanidins;synbiotics;mTOR;glucose homeostasis;type 2 diabetes

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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收录情况： SCI

摘要： This study investigated the protective role Of lotus seedpod oligomeric procyanidins (LSOPC) and synbiotics (Bifidobacterium Bb-12 and xylo-oligosaccharide) against high fat and streptozotocin (STZ)-induced diabetes. Administration of LSOPC or synbiotics had no effect on blood,glucose in normal mice. Treatments with LSOPC for 12 weeks markedly reduced blood glucose, FFA, endotoxin, and GHbA1c and improved glucose homeostasis, lipid metabolism, and insulin levels. In addition, administration of LSOPC significantly teversed the increase of mTOR and p66(shc) in liver, skeletal muscle, and White adipose tissue (WAT). LSOPC significantly increased glucose uptake and glycolysis in liver, skeletal muscle, and WAT while improving heat generation in brown adipose tissue (BAT) and inhibiting gluconeogenesis and lipogenesis in liver. Furthermore, synbiotics strengthened the improving effect of LSOPC. These findings demonstrated that LSOPC and synbiotics may regulate glucose disposal in peripheral target tissues through the p66(shc)-mTOR signaling pathway.

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