Comparison of anticancer activity and antioxidant activity between cyanidin-3-O-glucoside liposomes and cyanidin-3-O-glucoside in Caco-2 cells in vitro
文献类型： 外文期刊
作者： Liang, Tisong 1 ; Guan, Rongfa 1 ; Wang, Zhe 1 ; Shen, Haitao 2 ; Xia, Qile 3 ; Liu, Mingqi 1 ;
作者机构： 1.China Jiliang Univ, Zhejiang Prov Key Lab Biometrol & Inspect & Quara, Hangzhou 310018, Zhejiang, Peoples R China
2.Zhejiang Prov Ctr Dis Control & Prevent, 3399 Binsheng Rd, Hangzhou 310051, Zhejiang, Peoples R China
3.Zhejiang Acad Agr Sci, Food Sci Inst, 298 Desheng Rd, Hangzhou 310021, Zhejiang, Peoples R China
期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： In this study, we compared the antioxidant activities of cyanidin-3-O-glucoside (C3G) and C3G liposomes. We also compared the anticancer activities of C3G and C3G liposomes in Caco-2 cells. The radical scavenging activity of 2,2-diphenyl-1-picrylhydrazyl and the scavenging activity of 2,20-azinobis-3ethylbenzthiazoline- 6-sulfonic acid were used to evaluate the antioxidant activity of C3G and C3G liposomes. In addition, cell morphology, Cell Counting Kit-8 (CCK-8) assay, the microscopic structure of cells, and flow cytometry analysis were used to evaluate their anticancer activities. The CCK-8 assay results demonstrated that C3G and C3G liposomes reduced the mitochondrial activity of cells through dose effect, and the viabilities of Caco-2 cells were significantly decreased in vitro following exposure to C3G liposomes at 0.20 and 0.25 mg mL(-1) concentrations. The microscopic structure of cells exhibited the changes in the numbers and structures of mitochondria and fat droplet and the appearance of physalides, there by indicating that C3G liposomes affects the microscopic structure of cells. The CCK-8 evaluation of cell proliferation and the FCM analysis supported the anti-proliferative effects of C3G liposomes. Results demonstrated that the presence of C3G liposomes was more significant than that of C3G in inhibiting the proliferation of human tumor cells. Therefore, C3G liposomes have a potential therapeutic modality in tumor management.
- 相关文献
作者其他论文 更多>>
-
Chiral Nanoclusters as Alternative Therapeutic Strategies to Confront the Health Threat from Antibiotic-Resistant Pathogens
作者：Wang, Zhe;Tian, Yijin;Hao, Jinghua;Liu, Ya;Tang, Jie;Liu, Yin;Zhu, Nali;Li, Zhigang;Li, Lingxiangyu;Wang, Zhe;Tian, Yijin;Hao, Jinghua;Tang, Jie;Hu, Ligang;Wang, Yawei;Jiang, Guibin;Wang, Zhe;Tian, Yijin;Hao, Jinghua;Tang, Jie;Xu, Zhenlan;Tang, Biao;Huang, Xiu;Huang, Xiu
关键词：Antibacterial activity; chiral silver nanoclusters; antimicrobial resistance; cytocompatibility; Pseudomonas aeruginosa
-
Flavor characteristics of key aroma compounds in bayberry juice, fruit, and thinning fruit using HS-SPME coupled with GC/Q-TOF-MS
作者：Zhang, Suling;Wang, Xinquan;Liu, Lianliang;Qi, Peipei;Wang, Zhiwei;Di, Shanshan;Liu, Zhenzhen;Zhang, Suling;Zhao, Huiyu;Tang, Zhiwei;Xia, Qile;Zhang, Suling;Zhao, Huiyu;Tang, Zhiwei;Wang, Xinquan;Liu, Lianliang
关键词：SPME; GC-Q/TOF-MS; Flavor; Bayberry; ROAV
-
Transposable elements impact the population divergence of rice blast fungus Magnaporthe oryzae
作者：Lin, Lianyu;Sun, Ting;Guo, Jiayuan;Lin, Lili;Wang, Zhe;Zhang, Dongmei;Lu, Guodong;Zheng, Huakun;Zhong, Zhenhui;Wang, Zonghua;Guo, Jiayuan;Chen, Meilian;Han, Yijuan;Wang, Zonghua;Bao, Jiandong;Norvienyeku, Justice;Rensing, Christopher;Zhong, Zhenhui
关键词：transposable element; population divergence; rice subspecies adaptation; rice blast disease
-
Development and comprehensive SBSE-GC/Q-TOF-MS analysis optimization, comparison, and evaluation of different mulberry varieties volatile flavor
作者：Ma, Di;Zhao, Huiyu;Wang, Xinquan;Di, Shanshan;Liu, Zhenzhen;Qi, Peipei;Zhang, Suling;Jiao, Rui;Ma, Di;Wang, Xinquan;Liu, Mingqi;Jiao, Rui;Lin, Tianbao;Li, Yougui;Zhao, Huiyu;Wang, Xinquan
关键词：SBSE; Mulberry varieties; Volatile compounds; OAVs; Flavor; Odor ring charts
-
Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles
作者：Xia, Qile;Cao, Yan;Liang, Yan;Cai, Luyun;Liang, Yan;Cai, Luyun;Liang, Yan;Cai, Luyun;Cao, Ailing
关键词：Metal; Phlorotannins; Nanoparticles; pH-Responsive; Characterization
-
Optimizing the Solvent Selection of the Ultrasound-Assisted Extraction of Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Phenolic Profiles and Antioxidant Activity
作者：Wu, Dan;Yang, Zhihao;Huang, Huilin;Xia, Qile;Ye, Xingqian;Liu, Donghong;Li, Jiong;Xia, Qile
关键词：sea buckthorn pomace; solvent extraction; antioxidant activity; UPLC-MS/MS
-
Improving quality of sea buckthorn juice by high-pressure processing
作者：Xia, Qile;Liu, Chenxing;Cao, Yan;Lu, Shengmin;Aniya;Zhao, Yuqi;Wu, Dan;Guan, Rongfa
关键词：Sea buckthorn juice; High pressure processing; Thermal processing; Flavor; Overall quality
