Discovery and quantitative structure-activity relationship study of lepidopteran HMG-CoA reductase inhibitors as selective insecticides
文献类型： 外文期刊
作者： Zang, Yang-yang 1 ; Li, Yuan-mei 1 ; Yin, Yue 1 ; Chen, Shan-shan 2 ; Kai, Zhen-peng 1 ;
作者机构： 1.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai, Peoples R China
2.Shanghai Acad Agr Sci, Inst Agrofood Stand & Testing Technol, Shanghai, Peoples R China
关键词： JH biosynthesis;selective insecticides;HMG-CoA reductase inhibitors;structural comparison;CoMFA;gem-difluoromethylene substitution
期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：4.845； 五年影响因子：4.674 ）
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收录情况： SCI
摘要： BACKGROUNDIn a previous study we have demonstrated that insect 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) can be a potential selective insecticide target. Three series of inhibitors were designed on the basis of the difference in HMGR structures from Homo sapiens and Manduca sexta, with the aim of discovering potent selective insecticide candidates.
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