Determination of MS-222 in Water Samples by Solid-phase Extraction Coupled with Liquid Chromatography/Tandem Mass Spectrometry
文献类型： 外文期刊
作者： Zhao, Dong-Hao 1 ; Wang, Qiang 1 ; Wang, Xu-Feng 1 ; Li, Zhi-Guang 1 ; Li, Yong-Xian 1 ; Huang, Ke 1 ; Li, Liu-Dong 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Key Lab Aquat Prod Proc, Minist Agr, Guangzhou 510300, Guandong, Peoples R China; Chinese Acad Fishery Sci, Lab Qual & Safety Risk Assessment Aquat Prod Stor, Guangzhou 510300, Guandong, Peoples R China; Chinese Acad Fishery Sci, Fishery Environm & Aquat Prod Qual Inspect & Test, Minist Agr Guangzhou, Guangzhou 510300, Guandong, Peoples R China; Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangzhou 510300, Guandong, Peoples R China
期刊名称：JOURNAL OF CHROMATOGRAPHIC SCIENCE （ 影响因子：1.618； 五年影响因子：1.682 ）
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收录情况： SCI
摘要： A practical solid-phase extraction (SPE) method coupled with liquid chromatography/tandem mass spectrometry (LC-MS/MS) has been developed for the determination of the fish anesthetic MS-222 in water. Water samples were concentrated and purified using three SPE cartridges of different specifications. Elution curves of MS-222 were constructed using various methanol-water solutions on the different cartridges, and SPE conditions were optimized in accordance with the elution curves. The mobile phase containing methanol and 0.1% formic acid solution with a linear gradient elution was utilized to separate MS-222 on a C-18 column. Detection was carried out by a triple-quadrupole mass spectrometry with an electrospray ion source in positive mode. Recoveries of three MS-222 fortified levels of 0.05, 0.5 and 5 mu g/L ranged of 82.6-101% with relative standard deviations (RSDs) below 9.36%. The limit of detection (LOD) and limit of quantification (LOQ) of MS-222 were 0.01 mu g/L and 0.03 mu g/L, respectively. This method was satisfactorily applied to the determination of MS-222 in actual water samples collected from aquatic product transportation vehicles or from the natural water catchments.
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