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Tissue distribution and elimination of florfenicol in tilapia (Oreochromis niloticus x O-caureus) after a single oral administration in freshwater and seawater at 28 degrees C

文献类型： 外文期刊

作者： Feng, Jing-Bin 1 ; Jia, Xiao-Ping 2 ; Li, Liu-Dong 2 ;

作者机构： 1.Chinese Acad Sci, Key Lab Appl Marine Biol Guangdong Province, Guangzhou 510301, Guangdong, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab Marine Fishery Ecol Environm & Pollut Mon, S China Fisheries Inst, Guangzhou, Guangdong, Peoples R China

3.Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China

关键词： tilapia;florfenicol;distribution;elimination

期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）

ISSN： 0044-8486

年卷期： 2008 年 276 卷 1-4 期

页码：

收录情况： SCI

摘要： Tissue distribution and elimination of florfenicol in seawater-acclimated tilapia were compared with those in freshwater tilapia at 28 degrees C after they were given a single oral dose of 10 mg/kg body weight (b.w.). In most sampling time points, the concentrations of florfenicol in the tissues (muscle, liver, kidney, gill and bile) in freshwater tilapia were higher than those in seawater tilapia. In the major elimination phase the elimination half-lives (T-1/2 beta) in all the tissues (except for bile) of freshwater tilapia were longer than those in seawater tilapia. These findings indicated that the distribution level of florfenicol in freshwater tilapia was higher than that in seawater tilapia and the elimination of florfenicol in seawater tilapia was more rapid than that in freshwater tilapia. The main excretion pathway (gill excretion) of the drug in seawater-acclimated tilapia was different from that (bile excretion) in freshwater tilapia, which should be responsible for the considerable difference in pharmacokinetics from freshwater tilapia. (c) 2008 Elsevier B.V. All rights reserved.

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