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Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 degrees C

文献类型： 外文期刊

作者： Feng, Jing-Bin 1 ; Jia, Xiao-Ping 4 ;

作者机构： 1.Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China

2.Chinese Acad Sci, Key Lab Appl Marine Biol Guangdong Prov, Guangzhou 510301, Guangdong, Peoples R China

3.Chinese Acad Sci, Chinese Acad Sci LAMB, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China

4.Chinese Acad Fishery Sci, Key Lab Marine Fishery Ecol Environm & Pollut Mon, S China Fisheries Inst, Guangzhou, Guangdong, Peoples R China

关键词： Tilapia;Florfenicol;Pharmacokinetics;Distribution;Elimination

期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）

ISSN： 0044-8486

年卷期： 2009 年 289 卷 1-2 期

页码：

收录情况： SCI

摘要： Pharmacokinetics, tissue distribution and elimination of florfenicol in tilapia weighing about 98 g held in freshwater at 22 degrees C were studied after they were given a single oral dose of 10 mg kg(-1) body weight (b.w.). Five fish per sampling point were examined after treatment. Plasma, muscle, liver, kidney, bile and gill were collected and analysed by high-performance liquid chromatography (HPLC) method. Florfenicol was rapidly absorbed from intestine and distributed extensively to extravascular tissues. The maximum concentrations (C(max)) in both plasma and tissues were observed at 12 h (T(max)) and the maximum concentrations in the order of magnitude were bile (10.87 mu g g(-1))>kidney (6.89 mu g g(-1))>muscle (6.88 mu g g(-1))>liver (5.87 mu g g(-1))>plasma (4.46 mu g ml(-1))>gill (3.22 mu g g(-1)). The elimination of florfenicol was rapid in plasma, muscle, liver and gill tissue and relatively slow in kidney and bile. The elimination half-lives (T(1/2 beta)) in the order of magnitude were bile (36.29 h)>kidney (16.62 h)>gill (15.07 h)>liver (13.94 h)>muscle (10.97 h)>plasma (10.03 h). At 24 h after administration, the drug concentrations in both plasma and tissues remained above the effective treatment concentrations, which can be concluded by comparison with minimal inhibitory concentrations (MICs) as listed in literature, thus florfenicol can be considered as an appropriate treatment for common bacterial infections in fish farming. (C) 2008 Elsevier B.V. All rights reserved.

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