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Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle

文献类型： 外文期刊

作者： Huang, Yong-Zhen 1 ; Zou, Yong 1 ; Lin, Qing 2 ; He, Hua 1 ; Zheng, Li 3 ; Zhang, Zi-Jing 4 ; Dang, Yong-Long 1 ; Lei, Ch 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

2.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

3.Henan Univ Anim Husb & Econ, Zhengzhou 450046, Henan, Peoples R China

4.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 450002, Henan, Peoples R China

5.Bur Anim Husb, Biy

关键词： polymorphisms;Wnt8A gene;growth traits;Qinchuan cattle

期刊名称：JOURNAL OF GENETICS （ 影响因子：1.166； 五年影响因子：1.212 ）

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收录情况： SCI

摘要： WNT-beta-catenin-TCF pathway is involved in carcinogenesis and foetal development. As a member of the WNT gene family, Wnt8A encodes secreted signalling proteins and responds to many biological processes. However, similar research on the effects of genetic variations of Wnt8A gene on growth traits is lacking. Therefore, in this study, polymorphisms of Wnt8A were detected in 396 animals from Chinese Qinchuan cattle using DNA pool sequencing and PCR-RFLP methods. Four novel single-nucleotide polymorphisms (SNPs) of Wnt8A gene were identified, including three mutations in introns (g.T-445C, g.G244C and g.G910A) and one in exon (g.T4922C). Additionally, we examined the associations of four SNPs with growth traits. The results revealed that SNP2 (g.G244C) was significantly associated with shoulder height, hip height, body length, hip width, and body weight (P < 0.05). SNP3 (g.G910A) also displayed notable effects on hip width (P < 0.05). Meanwhile, the haplotype combination CC-GC-GA-CC was strongly associated with heavier, taller and longer animals (P < 0.05). These results show that the Wnt8A gene may be a potential candidate gene, and the SNPs could be used as molecular markers in early marker-assisted selection in beef cattle breeding programmes.

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