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Genetic characterization of novel reassortant H5N6-subtype influenza viruses isolated from cats in eastern China

文献类型： 外文期刊

作者： Cao, Xueliang 1 ; Yang, Fan 3 ; Wu, Haibo 3 ; Xu, Lihua 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Anim Husb & Vet Inst, 198 Shiqiao Rd, Hangzhou 310021, Zhejiang, Peoples R China

2.Dezhou Coll, Dezhou 253023, Shandong, Peoples R China

3.Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Sch Med,Affiliated Hosp 1, Collaborat Innovat Ctr Diag & Treatment Infect Di, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

关键词： Influenza A viruses;H5N6;Cat;Genetic analysis;Virus reassortment

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Cats are susceptible to influenza A viruses and therefore may act as transmission vectors within households, posing a potential public health concern. Two novel reassortant H5N6 influenza viruses were isolated from cats in Zhejiang Province, Eastern China, in 2016. Both viruses were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis showed that these viruses received their genes from H5N6, H9N2, and H7N9 influenza viruses isolated from China. These H5N6 viruses were able to replicate in mice without prior adaptation. Our results show that continued circulation of these viruses could endanger humans.

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