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The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis

文献类型： 外文期刊

作者： Liu, Ke-Han 1 ; Sun, Xiao-Feng 2 ; Feng, Yan-Zhong 3 ; Cheng, Shun-Feng 1 ; Li, Bo 4 ; Li, Ya-Peng 1 ; Shen, Wei 1 ; Li, 1 ;

作者机构： 1.Qingdao Agr Univ, Inst Reprod Sci, Coll Anim Sci & Technol, Qingdao 266109, Peoples R China

2.Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China

3.Heilongjiang Acad Agr Sci, Inst Anim Sci, Harbin 150086, Heilongjiang, Peoples R China

4.Chengguo Stn Anim Husb & Vet, Laizhou 261437, Peoples R China

关键词： ZEA;Mouse;Meiotic entry;DNA double-strand breaks;Primordial follicle assembly

期刊名称：TOXICOLOGY AND APPLIED PHARMACOLOGY （ 影响因子：4.219； 五年影响因子：4.302 ）

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收录情况： SCI

摘要： Abstract Zearalenone (ZEA) is a mycotoxin produced by fusarium graminearum. It can cause abnormal reproductive function by acting as an environmental estrogen. Research has traditionally focused on acute and chronic injury on mammalian reproductive capacity after ZEA treatment. Little research has been done studying the effects of ZEA exposure on early oogenesis. In this study, we investigate the effects of ZEA exposure on meiotic entry, DNA double-strand breaks (DSBs), and primordial follicle assembly during murine early oogenesis. The results show that ZEA exposure significantly decreased the percentage of diplotene stage germ cells, and made more germ cells remain at zygotene or pachytene stages. Moreover, the mRNA expression level of meiosis-related genes was significantly reduced after ZEA treatment. ZEA exposure significantly increased DNA-DSBs at the diplotene stage. Meanwhile, DNA damage repair genes such as RAD51 and BRCA1 were activated. Furthermore, maternal exposure to ZEA significantly decreased the number of primordial follicles in newborn mouse ovaries. In conclusion, ZEA exposure impairs mouse female germ cell meiotic progression, DNA-DSBs, and primordial follicle assembly. Highlights ? ZEA exposure inhibits meiotic progression of female germ cells. ? ZEA exposure increased DNA double-strand breaks at the diplotene stage. ? Maternal exposure to ZEA effects primordial follicle assembly in newborn ovaries. ]]>

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