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Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing

文献类型： 外文期刊

作者： Li, Qing 1 ; Lu, Fei 1 ; Zhou, Guofang 1 ; Yu, Kun 1 ; Lu, Bitao 1 ; Xiao, Yang 3 ; Dai, Fangying 1 ; Wu, Dayang 1 ; Lan, Gu 1 ;

作者机构： 1.Southwest Univ, Coll Text & Garments, Chongqing 400715, Peoples R China

2.Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China

3.Guangdong Acad Agr Sci, Sericulture & Agrifood Res Inst, Guangzhou 510610, Guangdong, Peoples R

期刊名称：BIOMACROMOLECULES （ 影响因子：6.988； 五年影响因子：6.813 ）

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收录情况： SCI

摘要： Silver inlaid with gold nanoparticles (Au–Ag NPs) prepared by using egg white with an average sized of 10 nm and homogeneous dispersion were tested and presented red fluorescence. Au–Ag NPs were loaded into chitosan as wound dressing (CS–Au–Ag). CS–Au–Ag released silver ions faster, in higher amount, and in a more durable manner than chitosan dressing loaded with silver nanoparticles with the same silver content (CS–Ag), consequently, showing enhanced antibacterial activity. Cytotoxicity tests indicated that CS–Au–Ag showed low cytotoxicity to L929 cells similar to CS–Ag. These data suggest that cytotoxicity, which restricts further application of silver NPs, can be eliminated by decreasing the silver content. CS–Au–Ag presented rich and well-distributed pores, good mechanical properties, and enhanced swelling and retention properties, contributing to keeping the wound moist in the presence of residual egg white. Altogether, our results suggest that CS–Au–Ag greatly promoted wound healing compared to CS–Ag in vivo, demonstrating that CS–Au–Ag presents great potential for wound dressing, promoting wound healing.

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