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Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics

文献类型： 外文期刊

作者： Zhao, Ran 1 ; Chen, Dong 1 ; Wu, Hualing 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Tea Res Inst, Guangzhou 510640, Guangdong, Peoples R China

2.Hunan Agr Univ, Key Lab, Minist Educ Tea Sci, Changsha 410128, Hunan, Peoples R China

3.Guangdong Key Lab Tea Plant Resources Innovat & U, Guangzhou 510640, Guangdong, Peoples R China

关键词： Pu-erh ripened tea;Metabolomics;GC–MS;Hyperuricemia

期刊名称：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES （ 影响因子：3.205； 五年影响因子：3.068 ）

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收录情况： SCI

摘要： Highlights?Serum metabolomics based on GC–MS was employed in this study.?Twelve potential biomarkers associated with hyperuricemia were identified.?Pu-erh ripened tea caused anti-hyperuricemia in mice.?A mechanism of Pu-erh ripened tea effects may be modifying amino acid metabolism.AbstractTo evaluate effects of Pu-erh ripened tea in hyperuricemic mice, a mouse hyperuricemia model was developed by oral administration of potassium oxonate for 7 d. Serum metabolomics, based on gas chromatography–mass spectrometry, was used to generate metabolic profiles from normal control, hyperuricemic and allopurinol-treated hyperuricemic mice, as well as hyperuricemic mice given Pu-erh ripened tea at three doses. Pu-erh ripened tea significantly lowered serum uric acid levels. Twelve potential biomarkers associated with hyperuricemia were identified. Pu-erh ripened tea and allopurinol differed in their metabolic effects in the hyperuricemic mice. Levels of glutamic acid, indolelactate, L-allothreonine, nicotinoylglycine, isoleucine,l-cysteine and glycocyamine, all involved in amino acid metabolism, were significantly changed in hyperuricemic mice treated Pu-erh ripened tea. Thus, modulating amino acid metabolism might be the primary mechanism of anti-hyperuricemia by Pu-erh ripened tea.]]>

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[1]Pu-erh ripened tea resists to hyperuricemia through xanthine oxidase and renal urate transporters in hyperuricemic mice. Zhao, Ran,Zhao, Ran,Chen, Dong,Wu, Hualing,Zhao, Ran,Chen, Dong,Wu, Hualing.

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