An exopolysaccharide from Lactobacillus pentosus YY-112: structure and effect on the human intestinal microbiota
文献类型： 外文期刊
作者： Yang, Ying 1 ; Wang, Mingzhe 1 ; Zhang, Hui 2 ; Zhou, Wanyi 1 ; Liu, Wei 1 ; Pi, Xionge 1 ; Xing, Jianrong 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Hangzhou 310021, Peoples R China
2.Univ Shanghai Sci & Technol, Shanghai 200093, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）
ISSN： 2042-6496
年卷期： 2023 年 14 卷 16 期
页码：
收录情况： SCI
摘要： The development of novel prebiotics, which could regulate the intestinal microbiota, may help prevent and treat intestinal diseases. Here, we studied a homogeneous polysaccharide, LPE-2, produced by Lactobacillus pentosus YY-112 during fermentation. Methylation and gas chromatography-mass spectrometry analysis, combined with nuclear magnetic resonance results, suggested that the structural unit of LPE-2 comprises a branched mannan moiety and a linear glucan moiety. In vitro simulated intestinal fermentation showed that LPE-2 reduced harmful intestinal gas production and promoted short-chain fatty acid production (especially propionic acid). Moreover, it reduced the relative abundance of Escherichia-Shigella, increased that of Bifidobacterium and Lactobacillus, and had a stronger regulatory effect on intestinal flora in women than in men. The potential sex-specific prebiotic effects of LPE-2 on human intestinal health, were possibly related to its mannan branch with (1 & RARR;2) and (1 & RARR;3) linkages and backbones with flexible & alpha; configurations, which are sheared and degraded/utilized easier by Bifidobacterium and Lactobacillus.
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