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Structural elucidation of a polysaccharide from &ITFlammulina velutipes &ITand its immunomodulation activities on mouse B lymphocytes

文献类型： 外文期刊

作者： Wang, Wen-Han 1 ; Zhang, Jing-Song 1 ; Feng, Ting 1 ; Deng, Jing; Lin, Chi-Chung 1 ; Fan, Hua; Yu, Wen-Juan; Bao 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi,Shanghai Key Lab A, Key Lab Appl Mycol Resources & Utilizat,Minist Ag, Shanghai 201403, Peoples R China

2.Jilin Agr Univ, Coll Chinese Tradit Med, Changchun, Jilin, Peoples R China

3.Jilin Agr Univ, Coll Chinese Tradit Med, Changchun, Jilin,

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2018 年 8 卷

页码：

收录情况： SCI

摘要： A novel polysaccharide FVPB2 was purified from fruiting bodies of Flammulina velutipes. Its structure was elucidated by monosaccharide composition and methylation analyses, UV-Visible and FTIR spectroscopy as well as NMR. FVPB2 was a homogeneous heteropolysaccharide (molecular weight -1.50 x 10(4) Da) containing D-galactose, D-mannose, L-fucose, and D-glucose at molar ratio of 1.9:1.2:1:2.5. In vitro immunomodulatory studies showed FVPB2 induced proliferation of mouse spleen lymphocytes in a dose-dependent manner. The levels of IgM and IgG, secreted by B cells, increased after FVPB2 treatment. So FVPB2 has potential to be a new important immunomodulatory nutraceutical.

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