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In vitro and in vivo antioxidative and radioprotective capacities of polysaccharide isolated from Mesona Blumes gum

文献类型: 外文期刊

作者: Feng, Tao 1 ; Sang, Min 1 ; Zhuang, Haining 1 ; Xu, Zhimin 1 ;

作者机构: 1.Shanghai Inst Technol, Sch Perfume & Aroma Technol, 100 Hai Quan Rd, Shanghai 201418, Peoples R China

2.Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South, Minist Agr,Natl Engn Res Ctr Edible Fungi,Natl R&, Shanghai, Peoples R China

3.Louisiana State Univ, Ctr Agr, Sch Nutr & Food Sci, Baton Rouge, LA 70803 USA

关键词: Antioxidant activity;In vitro;In vivo;Mesona Blumes;Polysaccharide

期刊名称:STARCH-STARKE ( 影响因子:2.741; 五年影响因子:3.112 )

ISSN: 0038-9056

年卷期: 2017 年 69 卷 11-12 期

页码:

收录情况: SCI

摘要: In this study, two extractable polysaccharides including AMBP and NMBP were isolated and purified from Mesona Blumes gum (MBG), and their antioxidative and radioprotective activities were investigated. The results indicate that AMBP showed a higher in vitro antioxidant activity than NMBP. AMBP presented a prominent DPPH free radical and superoxide radical scavenging activity, a moderate hydroxyl radical scavenging activity and ferrous ion chelating (FIC) activity. Furthermore, the antioxidant and radioprotective capacities of AMBP were investigated in vivo. AMBP significantly (p< 0.05) increased the hepatocytes activities of SOD, CAT, and GSH-Px and reduced the malonaldehyde (MDA) level in hepatocytes. Survival studies demonstrated that AMBP could expand the mean survival time and the survival percentage in a dose-dependent manner. AMBP could also prevent a decrease of the number of blood cells and the weight of the spleen and thymus. Therefore, AMBP possessed potent antioxidant activities and could assist with the recovery of the organ damage induced by irradiation. In conclusion, AMBP might be used as a supplement in the prevention of radiation poisoning as a functional food.

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