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Metabolomics in rare minnow (Gobiocypris rarus) after infection by attenuated and virulent grass carp reovirus genotype II

文献类型： 外文期刊

作者： Ma, Jie 1 ; Xu, Chen 2 ; Zhou, Yong 2 ; Jiang, Nan 2 ; Xue, Mingyang 2 ; Cao, Jiajia 2 ; Li, Shuang 2 ; Fan, Yuding 1 ;

作者机构： 1.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

3.Jiangxi Agr Univ, Coll Biol Sci & Engn, Nanchang 330045, Peoples R China

关键词： Metabolomics; Grass carp reovirus; Rare minnow; Gobiocypris rarus; Spleen; Hepatopancreas

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2023 年 138 卷

页码：

收录情况： SCI

摘要： Grass carp reovirus genotype II (GCRV II) causes hemorrhagic disease in a variety fish, seriously affecting the aquaculture industry in China. However, the pathogenesis of GCRV II is unclear. Rare minnow is an ideal model organism to study the pathogenesis of GCRV II. Herein, we applied liquid chromatography-tandem mass spec-trometry metabolomics to investigate metabolic responses in the spleen and hepatopancreas of rare minnow injected with virulent GCRV II isolate DY197 and attenuated isolate QJ205. Results indicated that marked metabolic changes were identified in both the spleen and hepatopancreas after GCRV II infection, and the virulent DY197 strain induced more significantly different metabolites (SDMs) than the attenuated QJ205 strain. Moreover, most SDMs were downregulated in the spleen and tend to be upregulated in hepatopancreas. The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that tissue-specific metabolic responses were identified after viruses infection, and the virulent DY197 strain induced more SDMs involved in amino acid metabolism in the spleen, especially the tryptophan metabolism, cysteine and methionine meta-bolism, which were essential for immune regulation in host; Meanwhile, nucleotide metabolism, protein syn-thesis and metabolism related pathways were enriched in the hepatopancreas by both virulent and attenuated strains. Our findings revealed the large scale metabolic alterations in rare minnow in response to attenuated and virulent GCRV II infection, which will lead to a better understanding of the pathogenesis of viruses and host-pathogens interactions.

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