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An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat

文献类型： 外文期刊

作者： Ru, Yan-Fei 1 ; Xue, Hai-Min 3 ; Ni, Zi-Mei 1 ; Xia, Dong 3 ; Zhou, Yu-Chuan 1 ; Zhang, Yong-Lian 1 ;

作者机构： 1.Chinese Acad Sci, Shanghai Key Lab Mol Androl, State Key Lab Mol Biol, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China

2.Univ Chinese Acad Sci, Beijing, Peoples R China

3.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai, Peoples R China

4.Shanghai Inst Planned Parenthood Res, Shanghai, Peoples R China

关键词： carboxylesterase;CES5A;epididymis;male fertility;sperm capacitation

期刊名称：ASIAN JOURNAL OF ANDROLOGY （ 影响因子：3.285； 五年影响因子：4.237 ）

ISSN： 1008-682X

年卷期： 2015 年 17 卷 2 期

页码：

收录情况： SCI

摘要： Despite the fact that the phenomenon of capacitation was discovered over half century ago and much progress has been made in identifying sperm events involved in capacitation, few specific molecules of epididymal origin have been identified as being directly involved in this process in vivo . Previously, our group cloned and characterized a carboxyl esterase gene Ces5a in the rat epididymis. The CES5A protein is mainly expressed in the corpus and cauda epididymidis and secreted into the corresponding lumens. Here, we report the function of CES5A in sperm maturation. By local injection of Lentivirus -mediated siRNA in the CES5A -expressing region of the rat epididymis, Ces5a -knockdown animal models were created. These animals exhibited an inhibited sperm capacitation and a reduction in male fertility. These results suggest that CES5A plays an important role in sperm maturation and male fertility.

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