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Quantitative assessment of risk associated with dietary intake of mycotoxin ochratoxin A on the adult inhabitants in Shanghai city of PR China

文献类型： 外文期刊

作者： Han, Zheng 1 ; Nie, Dongxia 1 ; Yang, Xianli 1 ; Wang, Jianhua 1 ; Peng, Shaojie 2 ; Wu, Aibo 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Agri Food Stand & Testing Technol, Minist Agr, Lab Qual & Safety Risk Assessment Agroprod Shangh, Shanghai 201403, Peoples R China

2.Inst Shanghai Food & Drug Supervis, Shanghai 200233, Peoples R China

3.Univ Ghent, Fac Pharmaceut Sci, Lab Food Anal, B-9000 Ghent, Belgium

关键词： Ochratoxin A;Risk assessment;Food consumption;Daily intake;Adult inhabitant

期刊名称：FOOD CONTROL （ 影响因子：5.548； 五年影响因子：5.498 ）

ISSN： 0956-7135

年卷期： 2013 年 32 卷 2 期

页码：

收录情况： SCI

摘要： Mycotoxin ochratoxin A (OTA) is considered to be a possible risk factor for adverse effects in humans. In the present study, quantitative assessment of risk associated with dietary intake of OTA was performed based on consumption habits of the representative adult inhabitants in Shanghai city of P. R. China. Firstly, a total of 400 food samples randomly collected from different locations of Shanghai were analyzed by the previously established isotope dilution LC-MS/MS method. Then, 265 participants of 70 males and 195 females as representative inhabitants were invited to answer the designed questionnaire about the quantity and frequency of foods including four major varieties of grapes, cereals, beans and dried fruits as well as their derived products. Finally, all data were simulated by the point evaluation and model evaluation for the risk assessment of OTA contamination. Results from the point evaluation indicated that mean value of daily intake (DI) of OTA was 1.147 ng/kg body weight/day, which was lower than all the reference standards. However, DI value (8.566 ng/kg body weight/day) in the high percentile (97.5th) was obviously higher than the PTDI (5 ng/kg body weight/day) proposed by Scientific Committee on Food. Among the different groups of foods, OTA in cereals and derived products made the largest contribution to the potential healthy risk. The mean DI value and 97.5th percentile were 1.093 and 7.962 ng/kg body weight/day, respectively, indicating that more than 90% of the risk was due to the contamination of OTA in cereals and derived products. On the other hand, similar results were obtained by the Monte Carlo assessment model. Thus, from the currently available data and analyzed results on the adult inhabitants, regarding OTA contamination issues on food safety administration of Shanghai, there was no significant attention which should be paid on food consumption in Shanghai, besides cereals and derived products with very little possibility as the risk factors. (C) 2013 Elsevier Ltd. All rights reserved.

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[1]In Vitro Glucuronidation of Ochratoxin A by Rat Liver Microsomes. Han, Zheng,Wu, Aibo,Han, Zheng,Tangni, Emmanuel K.,Callebaut, Alfons,Han, Zheng,Di Mavungu, Jose Diana,De Saeger, Sarah,Vanhaecke, Lynn. 2013

[2]Combinatorial approach of LC-MS/MS and LC-TOF-MS for uncovering in vivo kinetics and biotransformation of ochratoxin A in rat. Han, Zheng,Zhao, Zhiyong,Zhao, Zhihui,Wu, Aibo,Shi, Jianxin,Zhang, Dabing,Liao, Yucai,Wu, Yongning,Han, Zheng,De Saeger, Sarah.

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