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Determination of the full-genome sequence of hepatitis E virus (HEV) SAAS-FX17 and use as a reference to identify putative HEV genotype 4 virulence determinants

文献类型: 外文期刊

作者: Zhu, Yumin 1 ; Yu, Xiaoming 3 ; Huang, Fenfen 4 ; Yu, Ruisong 1 ; Dong, Shijuan 1 ; Si, Fusheng 1 ; Zhang, Yuanshu 3 ; Li 1 ;

作者机构: 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai 201106, Peoples R China

2.Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

3.Nanjing Agr Univ, Vet Coll, Nanjing 210095, Jiangsu, Peoples R China

4.Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang 330000, Jiangxi, Peoples R China

关键词: Hepatitis E virus;Disease severity determinant;Subtype;Genotype;Zoonosis

期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )

ISSN: 1743-422X

年卷期: 2012 年 9 卷

页码:

收录情况: SCI

摘要: Background: Four major genotypes of hepatitis E virus (HEV), the causative agent of hepatitis E, have so far been recognized. While genotypes 3 and 4 are both zoonotic, the disease symptoms caused by the latter tend to be more severe. To examine if specific nucleotide/amino acid variations between genotypes 3 and 4 play a role in determining the severity of hepatitis E disease, the complete genome of one swine HEV genotype 4 isolate, SAAS-FX17, was determined and compared with other genotype 4 and genotype 3 genomes to identify putative HEV genotype 4 virulence determinants. Results: A total of 42 conformable nt/aa variations between genotype 3 and 4 HEVs were detected, of which 19 were proposed to be potential disease severity determinants for genotype 4 strains. Conclusions: One potential determinant was located in each of the 5'-UTR and 3'-UTR, 3 and 12 within ORF1 and ORF2 respectively, and 2 in the junction region.

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