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Determination of the full-genome sequence of hepatitis E virus (HEV) SAAS-FX17 and use as a reference to identify putative HEV genotype 4 virulence determinants

文献类型： 外文期刊

作者： Zhu, Yumin 1 ; Yu, Xiaoming 3 ; Huang, Fenfen 4 ; Yu, Ruisong 1 ; Dong, Shijuan 1 ; Si, Fusheng 1 ; Zhang, Yuanshu 3 ; Li 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai 201106, Peoples R China

2.Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

3.Nanjing Agr Univ, Vet Coll, Nanjing 210095, Jiangsu, Peoples R China

4.Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang 330000, Jiangxi, Peoples R China

关键词： Hepatitis E virus;Disease severity determinant;Subtype;Genotype;Zoonosis

期刊名称：VIROLOGY JOURNAL （ 影响因子：4.099； 五年影响因子：3.719 ）

ISSN： 1743-422X

年卷期： 2012 年 9 卷

页码：

收录情况： SCI

摘要： Background: Four major genotypes of hepatitis E virus (HEV), the causative agent of hepatitis E, have so far been recognized. While genotypes 3 and 4 are both zoonotic, the disease symptoms caused by the latter tend to be more severe. To examine if specific nucleotide/amino acid variations between genotypes 3 and 4 play a role in determining the severity of hepatitis E disease, the complete genome of one swine HEV genotype 4 isolate, SAAS-FX17, was determined and compared with other genotype 4 and genotype 3 genomes to identify putative HEV genotype 4 virulence determinants. Results: A total of 42 conformable nt/aa variations between genotype 3 and 4 HEVs were detected, of which 19 were proposed to be potential disease severity determinants for genotype 4 strains. Conclusions: One potential determinant was located in each of the 5'-UTR and 3'-UTR, 3 and 12 within ORF1 and ORF2 respectively, and 2 in the junction region.

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[1]Molecular detection of hepatitis E virus in sheep from southern Xinjiang, China. Wu, Junyuan,Jin, Meilin,Wu, Junyuan,Jiang, Chunyu,Li, Tao,Si, Fusheng.

[2]Full genomic sequence analysis of swine genotype 3 hepatitis E virus isolated from Shanghai. Si, Fu-sheng,Zhu, Yu-min,Dong, Shi-juan,Yu, Shui-sheng,Yu, Rui-song,Shen, Shi-yuan,Li, Zhen,Zhu, Yu-min,Dong, Shi-juan,Yu, Shui-sheng,Yu, Rui-song,Shen, Shi-yuan,Li, Zhen,Si, Fu-sheng,Yang, Qian. 2009

[3]Molecular epidemiology of hepatitis E virus infections in Shanghai, China. Zhu, Yumin,Si, Fusheng,Yu, Xiaoming,Yu, Ruisong,Dong, Shijuan,Huang, Fenfen,Li, Zhen,Zhu, Yumin,Yu, Ruisong,Dong, Shijuan,Si, Fusheng,Yu, Xiaoming,Zhang, Yuanshu,Cao, Dianjun,Huang, Fenfen. 2011

[4]Exogenous nitric oxide protects against salt-induced oxidative stress in the leaves from two genotypes of tomato (Lycopersicom esculentum Mill.). Wu, Xuexia,Zhu, Weimin,Zhang, Hui,Ding, Haidong,Zhu, Weimin,Zhang, Hong Juan.

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