Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum
文献类型： 外文期刊
作者： Ji, Zhe 1 ; Tang, Qingjiu 2 ; Zhang, Jinsong 2 ; Yang, Yan 2 ; Jia, Wei 3 ; Pan, Yingjie;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201106, Peoples R China
2.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201106, Peoples R China; Nanjing Agr Univ, Key Lab Microbiol Engn Agr Environm, Minist Agr, Nanjing 210095, Jiangsu, Peoples R China; Shanghai Fisheries Univ, Shanghai 200090, Peoples R China
3.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201106, Peoples R China; Nanjing Agr Univ, Key Lab Microbiol Engn Agr Environm, Minist Agr, Nanjing 210095, Jiangsu, Peoples R China; Shanghai Fisheries Univ, Shangh
关键词： cytokines;Ganoderma lucidum (GL);immunoactivation
期刊名称：JOURNAL OF ETHNOPHARMACOLOGY （ 影响因子：4.36； 五年影响因子：4.488 ）
ISSN： 0378-8741
年卷期： 2007 年 112 卷 3 期
页码：
收录情况： SCI
摘要： The immunomodulatory effect of Ganoderma lucidum immunomodulating substance (GLIS) on macrophages has been investigated as part of on-going research into the anti-cancer properties of Ganoderma lucidum. Proliferation of bone marrow macrophages (BMMs) was enhanced by GLIS in a dose-dependent manner. Microscopic examination revealed that numerous GLIS-treated RAW264.7 macrophages were enlarged and formed pseudopodia. Exposure of RAW264.7 macrophages to GLIS resulted in significant increases in NO production, induction of cellular respiratory burst activity, and increased levels of IL-1 beta, IL-12p35 and IL-12p40 gene expression. Our data indicate that GLIS activates the immune system by modulating cytokine production. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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