文献类型： 外文期刊
作者： Yuan, Fangyan 1 ; Zheng, Lihan 2 ; Wang, Mengzhe 2 ; Liu, Wei 1 ; Li, Xiaoyue 2 ; Gao, Ting 1 ; Guo, Rui 1 ; Liu, Zewen 1 ; Yang, Keli 1 ; Li, Chang 1 ; Wu, Qiong 1 ; Zhu, Jiajia 1 ; Tian, Yongxiang 1 ; Zhou, Danna 1 ;
作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Key Lab Prevent & Control Agents Anim Bacteriosis, Hubei Prov Key Lab Anim Pathogen Microbiol,Minist, Wuhan 430064, Peoples R China
2.Huazhong Agr Univ, Coll Vet Med, Cooperat Innovat Ctr Sustainable Pig Prod, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
关键词：
phillyrin;
期刊名称：BIOMOLECULES （ 影响因子：4.8； 五年影响因子：5.6 ）
ISSN：
年卷期： 2024 年 14 卷 12 期
页码：
收录情况： SCI
摘要： As a zoonotic pathogen, S. suis serotype 2 (SS2) can cause severe diseases in both pigs and humans, and develop resistance to antibiotics. Plant natural compounds are regarded as promising alternatives to conventional antibiotics. Phillyrin is the major bioactive components of Chinese herbal medicine Forsythia suspensa. In this study, we explored the activity and action mechanism of phillyrin against SS2. The results showed that phillyrin could disrupt membrane integrity, destroy intracellular structures, and increase the exosmosis of DNA. Results of PCR revealed that phillyrin affected bacterial-virulence-related genes' expression levels. Meanwhile, phillyrin significantly decreased the adhesion activity, inhibited lactate dehydrogenase (LDH) secretion, and reduced biofilm formation of SS2 in Newborn pig trachea epithelial (NPTr) cells. Furthermore, phillyrin protected tight junction protein of NPTr cells from SS2. We reported that phillyrin (0.1 mg/kg) treatment after bacterial challenge significantly improved the survival rate, ameliorated pulmonary inflammation, and inhibited the accumulation of multiple cytokines (IL-1, IL-6, IL-8, and TNF-alpha). Molecular docking showed that phillyrin had a good binding activity with the Ala88 and Asp111 of suilysin (SLY), one of the most important virulence factors of SS2. Collectively, phillyrin possesses antibacterial and anti-inflammatory activities, and is a promising candidate for preventing SS2 infection.
- 相关文献
作者其他论文 更多>>
-
LACCASE35 enhances lignification and resistance against Pseudomonas syringae pv. actinidiae infection in kiwifruit
作者：Li, Yawei;Zhang, Dongle;Wang, Xiaojie;Wu, Shunyuan;Liu, Pu;Wang, Xiaojie;Zhou, Rongrong;Fang, Zemin;Bai, Fuxi;Li, Rui;Liu, Wei;Huang, Lili
关键词：
-
The role of visfatin in peripheral immune organs and intestines of weaned piglets under lipopolysaccharide induced immune stress
作者：Li, Huizhen;Niu, Xiaoyu;Xu, Fenliang;Ansari, Abdur Rahman;Pang, Xinxin;Song, Hui;Li, Huizhen;Ansari, Abdur Rahman;Ansari, Abdur Rahman;Zou, Weihua;Yang, Keli
关键词：Visfatin; Weaned piglets; Immune stress; Spleen; Mesenteric lymph nodes; Intestinal balance
-
Flavonoids as Promising Natural Compounds for Combating Bacterial Infections
作者：Liu, Ying;Liu, Zhenyi;Zhi, Yan;Mei, Chen;Wang, Hongjun;Zhu, Jiajia
关键词：antibiotic resistance; multidrug-resistant bacteria; flavonoids; natural antimicrobial compounds; bacterial infections
-
Identification of SepF in Streptococcus suis involving cell division
作者：Gao, Ting;Zhu, Jiajia;Liu, Wei;Yang, Keli;Zhang, Tengfei;Yuan, Fangyan;Liu, Zewen;Guo, Rui;Li, Chang;Wu, Qiong;Tian, Yongxiang;Zhou, Danna;Li, Tingting;Zheng, Linlin;Zhou, Rui;Zheng, Linlin;Chen, Mo
关键词：
Streptococcus suis ; Cell division; Septum; Protein-protein interaction; Drug target -
Prediction of Three Sediment Phosphorus Indexes on Water Column Phosphorus Across Seasons in the Xiashan Reservoir, Northern China
作者：Liu, Wei;Hu, Fang;Fu, Songjie;Yu, Yongchao;Jiang, Shan;Liang, Lanwei;Chen, Xuemei;Jiao, Yang;Gu, Sen;Li, Qingman;Hu, Fang;Fu, Songjie;Yu, Yongchao;Jiang, Shan;Liang, Lanwei;Liu, Zhenjun;Chen, Xuemei;Jiao, Yang;Gu, Sen;Li, Qingman
关键词：sediment; phosphorus; internal loading; freshwater reservoir; risk assessment; eutrophication
-
Antibacterial activity of a plant natural poly-phenol against zoonotic Streptococcus suis
作者：Gao, Ting;Wang, Yanjun;Zhu, Jiajia;Chen, Mo;Yang, Keli;Yuan, Fangyan;Liu, Zewen;Liu, Wei;Guo, Rui;Li, Chang;Wu, Qiong;Tian, Yongxiang;Zhou, Danna;Wang, Yanjun;Li, Lu;Chen, Mo;Tian, Haibin
关键词：Streptococcus suis; Plant resource; Poly-phenol; Biofilm; Antibiotic alternative; Antibiotic adjuvant
-
Preparation and Evaluation of Novel Epitope-Based ETEC K88-K99 Bivalent Vaccine
作者：Wang, Shuangshuang;Yue, Xinru;Bei, Weicheng;Wang, Shuangshuang;Yue, Xinru;Bei, Weicheng;Wang, Shuangshuang;Yue, Xinru;Bei, Weicheng;Wang, Shuangshuang;Yang, Yuxin;Yue, Xinru;Liu, Zewen;Yuan, Fangyan;Yang, Keli;Zhu, Jiajia;Liu, Wei;Tian, Yongxiang;Wu, Qiong;Gao, Ting;Li, Chang;Song, Haofei;Zhou, Danna
关键词：Enterotoxigenic Escherichia coli; FaeG; FanC; epitope; vaccine
