Effect of temperate bacteriophage vB_SauS_S1 on the adaptability and pathogenicity of Staphylococcus aureus ST398
文献类型： 外文期刊
作者： Liu, Hui 1 ; Billington, Craig 3 ; Ji, Xing 1 ; Sun, Haichang 1 ; Hou, Xiang 1 ; Soleimani-Delfan, Abbas 1 ; Wang, Ran 1 ; Wang, Heye 1 ; Zhang, Lili 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Key Lab Food Qual & Safety Jiangsu Prov, State Key Lab Breeding Base, Nanjing 210014, Peoples R China
2.Guangxi Univ, Coll Anim Sci & Technol, Nanning 530004, Guangxi, Peoples R China
3.Inst Environm Sci & Res, 27 Creyke Rd, Christchurch 8041, New Zealand
4.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
关键词： ST398; Temperate phage; Lysogen; Adaptability; Pathogenicity
期刊名称：BMC MICROBIOLOGY （ 影响因子：4.2； 五年影响因子：4.8 ）
ISSN： 1471-2180
年卷期： 2025 年 25 卷 1 期
页码：
收录情况： SCI
摘要： Livestock-associated Staphylococcus aureus ST398 is a highly pathogenic species that causes infections in a wide variety of animals, including humans. The bacteriophage (phage) vB_SauS_S1 was isolated originally using a ST398 strain as its "isolating host", then the spot tests showed it was able to infect 73.33% (22/30) ST398 isolates. Phage S1 was assigned as a temperate phage based on genome analysis and phenotypic validation. Phylogenetic analysis showed that S1 was closely related to temperate phages tp310-2 and SA137ruMSSAST121PVL. Following infection of ST398 by phage S1, the lysogenic strain showed enhanced biofilm forming ability compared to the wildtype strain, and the invasion rate of MAC-T cells increased by 10.39%. The minimum inhibitory concentration showed that phage S1 did not change the antibiotic sensitivity of the lysogen strain, and the virulence of the lysogen strain did not change significantly in the injection models of Galleria mellonella (G. mellonella) and mice. The lysogen demonstrated superinfection immunity and reduced sensitivity to virulent phage infection. Thus, this study contributes to understanding the co-evolutionary relationships between temperate phages and the multi-host zoonotic pathogen S. aureus ST398.
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