The chromosome-level genome and key genes associated with mud-dwelling behavior and adaptations of hypoxia and noxious environments in loach (Misgurnus anguillicaudatus)
文献类型： 外文期刊
作者： Sun, Bing 1 ; Huang, Yuwei 1 ; Castro, L. Filipe C. 2 ; Yang, Su 1 ; Huang, Songqian 4 ; Jin, Wu 5 ; Zhou, He 6 ; Ijiri, Shigeho 7 ; Luo, Yi 1 ; Gao, Jian 1 ; Cao, Xiaojuan 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Engn Res Ctr Green Dev Convent Aquat Biol Ind Yang, Minist Educ, 1 Shizishan Stress, Wuhan 430070, Hubei, Peoples R China
2.Univ Porto, Interdisciplinary Ctr Marine & Environm Res, P-4450208 Matosinhos, Portugal
3.Univ Porto, Dept Biol, P-4450208 Porto, Portugal
4.Univ Tokyo, Grad Sch Agr & Life Sci, Dept Aquat Biosci, Bunkyo Ku, Tokyo 1138657, Japan
5.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Jiangsu, Peoples R China
6.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China
7.Hokkaido Univ, Grad Sch Fisheries Sci, Div Marine Life Sci, Hakodate, Hokkaido 0418611, Japan
关键词： Misgurnus anguillicaudatus; Chromosome-anchored genome assembly; Biological adaptations; Mud-dwelling behavior; Intestinal air-breathing; Detoxification function
期刊名称：BMC BIOLOGY （ 影响因子：5.4； 五年影响因子：7.1 ）
ISSN：
年卷期： 2023 年 21 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundThe loach (Misgurnus anguillicaudatus), the most widely distributed species of the family Cobitidae, displays a mud-dwelling behavior and intestinal air-breathing, inhabiting the muddy bottom of extensive freshwater habitats. However, lack of high-quality reference genome seriously limits the interpretation of the genetic basis of specialized adaptations of the loach to the adverse environments including but not limited to the extreme water temperature, hypoxic and noxious mud environment.ResultsThis study generated a 1.10-Gb high-quality, chromosome-anchored genome assembly, with a contig N50 of 3.83 Mb. Multiple comparative genomic analyses found that proto-oncogene c-Fos (fos), a regulator of bone development, is positively selected in loach. Knockout of fos (ID: Mis0086400.1) led to severe osteopetrosis and movement difficulties, combined with the comparison results of bone mineral density, supporting the hypothesis that fos is associated with loach mud-dwelling behavior. Based on genomic and transcriptomic analysis, we identified two key elements involved in the intestinal air-breathing of loach: a novel gene (ID: mis0158000.1) and heat shock protein beta-1 (hspb1). The flavin-containing monooxygenase 5 (fmo5) genes, central to xenobiotic metabolism, undergone expansion in loach and were identified as differentially expressed genes in a drug stress trial. A fmo5(-/-) (ID: Mis0185930.1) loach displayed liver and intestine injury, indicating the importance of this gene to the adaptation of the loach to the noxious mud.ConclusionsOur work provides valuable insights into the genetic basis of biological adaptation to adverse environments.
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