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Effects of dietary melatonin on antioxidant and immune function of the Pacific white shrimp (Litopenaeus vannamei), as determined by transcriptomic analysis

文献类型： 外文期刊

作者： Li, Yiming 1 ; Yang, Ying 2 ; Li, Siwen 2 ; Ye, Yucong 2 ; Du, Xinglin 2 ; Liu, Xingguo 1 ; Jiang, Qichen 3 ; Che, Xuan 1 ;

作者机构： 1.Chinese Acad Fisheries Sci, Fishery Machinery & Instrument Res Inst, Shanghai 200092, Peoples R China

2.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China

3.Freshwater Fisheries Res Inst Jiangsu Prov, Nanjing 210017, Peoples R China

4.Chinese Acad Fisheries Sci, Fishery Machinery & Instrument Res Inst, 63 Chifeng Rd, Shanghai 200092, Peoples R China

关键词： Melatonin; Antioxidant immunity; Transcriptomic analysis; Litopenaeus vannamei

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 1744-117X

年卷期： 2023 年 48 卷

页码：

收录情况： SCI

摘要： Melatonin (MT) is regarded as an antioxidant and immunostimulant that can efficiently scavenge free radicals and activate antioxidant enzymes. The aim of this study was to investigate the effects of dietary MT on the growth performance and immune function of the Pacific white shrimp (Litopenaeus vannamei). Six groups of L. vannamei were supplemented with dietary MT at 0, 22.5, 41.2, 82.7, 165.1, and 329.2 mg/kg levels for 2 months. RNA-Seq analysis was performed to obtain transcriptome data of the control group and the group supplemented with dietary MT at 82.7 mg/kg BW. In total, 1220 DEGs (799 up-regulated and 421 downregulated) were identified. Pathways and genes related to growth performance and immune function were verified by real-time quantitative polymerase chain reaction. The total hemocyte count, phagocytosis rate, and respiratory burst were significantly increased in the MT (82.7 mg/kg BW) group as compared to the control group. Analysis of antioxidant-related enzymes in the hepatopancreas showed that dietary MT (82.7 mg/kg BW) significantly increased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase, while dietary MT at 41.2 mg/kg BW significantly increased activities of glutathione S-transferase, lysozyme (LZM), and phenoloxidase (PO). At the transcriptional level, dietary MT up-regulated expression levels of genes associated with antioxidant immunity and growth, which included PO, SOD, LZM, GPx, chitin synthase, ecdysone receptor, calcium-calmodulin dependent protein kinase I, and retinoid X receptor. In conclusion, dietary MT may improve the growth performance and immune function of L. vannamei to some extent.

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