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Screening for S32G mutation of BMP15 gene in 18 goat breeds

文献类型： 外文期刊

作者： Feng, Tao 1 ; Chu, Ming-Xing 2 ; Cao, Gui-Lin 2 ; Huang, Dong-Wei 2 ; Di, Ran 2 ; Liu, Qiu-Yue 2 ; Pan, Zhang-Yuan 2 ; Ji 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing, Peoples R China

2.Chinese Acad Agr Sci, Inst Anim Sci, Minist Agr, Key Lab Farm Anim Genet Resources & Germplasm Inn, Beijing 100193, Peoples R China

3.Liaoning

关键词： Goat;prolificacy;bone morphogenetic protein 15 gene;functional analysis

期刊名称：TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES （ 影响因子：0.581； 五年影响因子：0.78 ）

ISSN： 1300-0128

年卷期： 2014 年 38 卷 5 期

页码：

收录情况： SCI

摘要： In our early work, one mutation (A898G, which caused Ser32Gly (S32G) change of mature peptide) was identified in the goat BMP15 gene and the allele G was associated with high litter size in fining Grey goats (the goat breed with the highest fecundity in China). The aim of this research was to investigate the genetic structure of the prolific BMP15 gene in 18 goat breeds reared in China, including 12 native breeds, 3 introduced breeds, and 2 cultivated breeds. Genomic DNA of 1011 goats was screened for the S32G mutation. The results showed that this mutation existed in all 3 cultivated and 8 native goat breeds but in none of the 3 introduced goat breeds, which hinted that this mutation may originate from native goat breeds of China. Besides the fining Grey goats, the BMP15 gene was also a potential prolificacy gene in Matou goats. Moreover, the structure prediction indicated that the S32G mutation might participate in the binding of BMP15 with receptors.

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