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Expression profiling and single nucleotide polymorphism of mitogen-activated protein kinase kinase kinase 8 MAP3K8 in white muscovy ducks (Cairina moschata)

文献类型: 外文期刊

作者: Bello, Semiu Folaniyi 1 ; Xu, Haiping 1 ; Bolaji, Umar-Faruq Olayinka 5 ; Aloryi, Kelvin Dodzi 6 ; Adeola, Adeniyi Charles 7 ; Gibril, Bahareldin Ali Abdalla 8 ; Popoola, Moshood Abiola 9 ; Zhu, Weijian 11 ; Zhang, Dexiang 1 ; Zhang, Xiquan 1 ; Ji, Congliang 11 ; Nie, Qinghua 1 ;

作者机构: 1.South China Agr Univ, Coll Anim Sci, Dept Anim Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China

2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou 510642, Guangdong, Peoples R China

3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China

4.Org African Acad Doctors OAAD, Agr Res Grp, Off Kamiti Rd,POB 25305-00100, Nairobi, Kenya

5.King Saud Univ, Coll Food & Agr Sci, Dept Anim Prod, Riyadh, Saudi Arabia

6.Univ Florida, Dept Hort Sci, Gainesville, FL USA

7.Chinese Acad Sci, Kunming Inst Zool, Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China

8.Nanchang Normal Univ, Inst Biol Technol, Jiangxi Prov Key Lab Poultry Genet Improvement, Nanchang 330032, Peoples R China

9.Apata, Moor Plantat, Fed Coll Anim Hlth & Prod Technol, Ibadan, Nigeria

10.Natl Dairy Res Inst, Karnal, India

11.Wens Foodstuff Grp Co Ltd, Yunfu 527400, Guangdong, Peoples R China

关键词: Egg production traits; Single nucleotide polymorphism; Expression level; White Muscovy duck; MAP3K8

期刊名称:GENE ( 影响因子:2.4; 五年影响因子:2.8 )

ISSN: 0378-1119

年卷期: 2025 年 932 卷

页码:

收录情况: SCI

摘要: A previous study on ovarian and hypothalami transcriptome analysis in white Muscovy duck revealed that MAP3K8 gene participated in MAPK signaling pathway that influence egg production. Additionally, MAP3K8 was predicted as a target gene of miRNA-509-3p that promotes the secretion of oestradiol which is an important hormone in egg ovulation. This suggested that MAP3K8 might have a functional role in the reproductive performance "egg production" of white Muscovy ducks. Herein, we focused on expression level of MAP3K8 in reproductive and non-reproductive tissues of highest (HP) and lowest (LP) egg producing white Muscovy ducks and identified the polymorphism in MAP3K8 and its association with three egg production traits; Age at first egg (AFE), number of eggs at 300 days (N300D) and 59 weeks (N59W). The results of expression level indicated that mRNA of MAP3K8 was significantly (p <0.01) expressed in the oviduct than in the ovary and hypothalamus. Seven synonymous SNPs were detected, and association analysis showed that g.148303340 G>A and g.148290065 A>G were significantly (p < 0.05) associated with N300D and N59W. The results of this study might serve as molecular marker for marker-assisted selection of white Muscovy ducks for egg production.

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