Differential activation of six galanin receptors by the spexin peptide in yellowtail kingfish ( Seriola lalandi)
文献类型： 外文期刊
作者： Wang, Bin 1 ; Tian, Zhenfang 1 ; Yu, Zhihua 1 ; Cui, Aijun 1 ; Jiang, Yan 1 ; Huang, Hai 4 ; Xu, Yongjiang 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Peoples R China
2.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
3.Ocean Univ China, Fisheries Coll, Qingdao 266003, Peoples R China
4.Hainan Trop Ocean Univ, Key Lab Utilizat & Conservat Trop Marine Bioresour, Minist Educ, Sanya 572022, Peoples R China
关键词： Spexin; Galanin receptor; Signaling pathway; PKA; PKC; Ca2+
期刊名称：GENERAL AND COMPARATIVE ENDOCRINOLOGY （ 影响因子：1.7； 五年影响因子：2.2 ）
ISSN： 0016-6480
年卷期： 2024 年 359 卷
页码：
收录情况： SCI
摘要： Spexin (SPX1) is a novel neuropeptide composed of 14 amino acids and well conserved across vertebrates, and it has been implicated in various physiological functions via galanin receptor 2 (GALR2) and GALR3. However, the detailed signaling pathways mediating its actions in target cells are still largely unknown. Accordingly, we addressed this issue in the present study using yellowtail kingfish as a model. SPX1 significantly increased CREluc activity in COS-7 cells expressing its cognate receptors GALR2a and GALR2b, and this stimulatory effect was attenuated by two inhibitors of the PKA pathway. Similarly, an evident induction of SRE-luc activity was observed when COS-7 cells transfected with GALR1b, GALR2a, GALR2b, GALR type 1, or GALR type 2 were challenged with SPX1, and two blockers of the PKC pathway suppressed this stimulatory action. Moreover, SPX1 markedly elevated NFAT-RE-luc activity in COS-7 cells expressing GALR1a, GALR2a, or GALR2b, and this promotion was inhibited by two antagonists of the Ca2+ route. Overall, our results have revealed that activation of six yellowtail kingfish galanin receptors by the SPX1 peptide may occur with different downstream signaling events, which could account for its pleotropic functions.
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