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Novel Haplotype in the HHEX Gene Promoter Associated with Body Length in Pigs

文献类型： 外文期刊

作者： Luo, Yabiao 1 ; Xu, Qiao 1 ; Xue, Mingming 1 ; Wang, Yubei 1 ; Yang, Xiaoyang 1 ; Chan, Shuheng 1 ; Tang, Qiguo 1 ; Wang, Feng 3 ; Sun, Ruiping 3 ; Chao, Zhe 3 ; Fang, Meiying 1 ;

作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, MOA Lab Anim Genet & Breeding, Natl Engn Lab Anim Breeding,Dept Anim Genet & Bree, Beijing 100193, Peoples R China

2.Nanchang Normal Univ, Inst Biol Technol, Jiang Xi Prov Key Lab Genet Improvement Indigenous, Nanchang 330029, Peoples R China

3.Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Haikou 571100, Peoples R China

4.China Agr Univ, Sanya Inst, Sanya 572025, Peoples R China

关键词： HHEX; body length; expression pattern; gene polymorphism; promoter activity

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 2 期

页码：

收录情况： SCI

摘要： The screening of important candidate genes and the identification of genetic markers are important for molecular selection in the pig industry. The hematopoietically expressed homeobox (HHEX) gene plays an important role in embryonic development and organogenesis; however, the genetic variation and expression pattern of the porcine HHEX gene remains to be clarified. In this study, semiquantitative RT-PCR and immunohistochemistry results showed the specific expression of the HHEX gene in porcine cartilage tissues. A novel haplotype consisting of two SNPs rs80901185 (T > C) and rs80934526 (A > G) was detected in the promoter region of the HHEX gene. The expression of the HHEX gene was significantly higher in Yorkshire pigs (TA haplotype) than in Wuzhishan pigs (CG haplotype), and a population analysis showed that this haplotype was significantly associated with body length. An analysis subsequently revealed that the -586 to -1 bp region of the HHEX gene promoter showed the highest activity. Furthermore, we found that the activity of the TA haplotype was significantly higher than that of the CG haplotype by changing the potential binding of transcription factors YY1 and HDAC2. In summary, we conclude that the porcine HHEX gene may contribute to the breeding of pigs for body length traits.

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