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Genome-wide association studies and haplotype sharing analysis targeting the growth traits in Yandang partridge chickens

文献类型： 外文期刊

作者： Wu, Chunqin 1 ; Dong, Liyan 1 ; Gan, Xiantong 2 ; Gan, Fangben 2 ; Xu, Wenwu 3 ; Lu, Lizhi 3 ;

作者机构： 1.Wenzhou Vocat Coll Sci & Technol, Wenzhou, Peoples R China

2.Zhejiang Lvyan Agr Dev Co Ltd, Yueqing, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310022, Peoples R China

关键词： GWAS; haplotype; growth traits; Yandang partridge chickens

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）

ISSN： 1049-5398

年卷期：

页码：

收录情况： SCI

摘要： The body size of a chicken is an economically important trait as it directly influences the benefits of the poultry industry, but the relevant genetic mechanisms have not yet been elucidated. In this study, we measured eight growth traits for 94 Yandang partridge chickens, then undertook genome-wide association studies (GWAS) for those traits in using a linear mixed model based on 10x whole genomic sequencing data to better understand the knowledge of the genetic architecture of growth traits. Ninety-four individuals and 7647883 SNPs remained after quality control and removal of the sex chromosomes, and these data were used to carry out a GWAS analysis. The result showed that only one significant single-nucleotide polymorphisms (SNP) locates at 14852873 bp on SSC13 surpassed the genome-wide significance level for Keel length (KL). Through linkage disequilibrium analysis and haplotype sharing analysis, we identified one haplotype underlying the SSC13 significantly associated with KL, which could be selected as a potential candidate haplotype that is used in molecular breeding of Yandang partridge chicken. On the other hand, we have learned from a method called bootstrap testing to verify the reliability of GWAS with small experimental samples, which users can access at https://github.com/xuwenwu24/Bootstrap-test.

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