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Copy number variations of LRRFIP1 gene and the relationship with growth traits in four Chinese sheep

文献类型： 外文期刊

作者： Wen, Yifan 1 ; Wang, Eryao 2 ; Wang, Xianwei 3 ; Qing, Si 4 ; Chaogetu, Buren 5 ; Wang, Chenglin 5 ; Xu, Zejun 3 ; Zhang, Zijing 2 ; Huang, Yongzhen 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

2.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 45002, Henan, Peoples R China

3.Henan Prov Anim Husb Gen Stn, Zhengzhou, Henan, Peoples R China

4.Qual & Safety Inspect & Testing Ctr Agr & Livesto, Delingha, Qinghai, Peoples R China

5.Agr & Anim Husb Technol Promot Serv Ctr Haixi Mon, Delingha, Qinghai, Peoples R China

关键词： Copy number variations (CNVs); LRRFIP1 gene; growth traits; Chinese sheep

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）

ISSN： 1049-5398

年卷期：

页码：

收录情况： SCI

摘要： CNVs (copy number variations) are the novel and common structural variants that could cover entire genes found in plenty of species. CNV may influence economically important traits or disease susceptibility in livestock species. Based on the whole genome resequencing results, we found that there was a CNV region on the LRRFIP1 gene. Then we used qPCR to detect the copy number type distribution in 553 individuals of four sheep breeds and used them for association analysis. The results showed that: (1) In the CKS, the sheep with gain type had a larger heart girth (p = 0.049). (2) For the HS, the CNV could significantly affect rump breadth (p = 0.037) and circumference of the cannon (p = 0.035). And the sheep with median type showed better performance in rump breadth and circumference of cannon. (3) At the STHS, the CNV was significantly correlated with chest width (p = 0.000) with loss type as the most favorable CNV type. Meanwhile, the best was the loss type, and the lowest was the median. (4) This CNV had no significant effect on the LTHS. So, the CNV of LRRFIP1 was related to the growth traits of these three sheep breeds and it may be used as a molecular marker for sheep.

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