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Genome-Wide Association Study That Identifies Molecular Markers with Freezing Resistance in Duroc Boar Sperm

文献类型： 外文期刊

作者： Zhang, Jiajun 1 ; Li, Meicheng 1 ; Chen, Guangxiang 2 ; Tao, Chenyu 1 ; Li, Bushe 3 ; Zhang, Hejun 3 ; Wang, Hongyang 4 ; Wang, Wenjun 1 ;

作者机构： 1.Hebei Agr Univ, Coll Anim Sci & Technol, Baoding 071000, Peoples R China

2.Hebei Agr Univ, Expt & Training Ctr, Baoding 071000, Peoples R China

3.Shanghai Engn Res Ctr Breeding Pig, Shanghai 201106, Peoples R China

4.Shanghai Acad Agr Sci, Inst Anim Husb &Veterinary Sci, Key Lab Livestock & Poultry Resources Pig Evaluat, Minist Agr & Rural Affairs, Shanghai 201106, Peoples R China

关键词： Duroc; GWAS; boar sperm freezability; biomarker; candidate gene

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2025 年 15 卷 10 期

页码：

收录情况： SCI

摘要： Semen cryopreservation is a crucial technology in the artificial insemination of livestock and poultry. It not only contributes to the conservation of germplasm resources but also facilitates the cross-regional exchange of high-quality breeding stock. In this study, 165 Duroc boars were selected for genome-wide genotyping, and the sperm freezing/thawing motility ratio (sperm recovery rate) was used as phenotypic data for genome-wide association analysis (GWAS). Considerable individual variations in sperm recovery rates (SRRs) were detected, and the sperm structure after cyropreservation was significantly better in highly freeze-tolerant individuals compared to non-freeze-tolerant ones. The heritability of the SRR was calculated and found to be 0.199 +/- 0.158, representing low heritability. Through GWAS, eight single-nucleotide polymorphism (SNP) loci and four candidate genes (SLC10A6, MYRF, GGA1, and UTRN) were identified as being significantly associated with sperm freezing tolerance. Moreover, the dominant genotypes of four SNPs were finally determined to be valuable for identifying individuals with high sperm freezing tolerance. This study reveals the heritability of the sperm recovery rate and identifies molecular markers associated with sperm freezing tolerance in Duroc boars, which is of great significance for accelerating boar genetic improvement and enhancing the economic efficiency of pig breeding industry.

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