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Higher tolerance of predominant Salmonella serovars circulating in the antibiotic-free feed farms to environmental stresses

文献类型： 外文期刊

作者： Li, Yan 1 ; Ed-Dra, Abdelaziz 2 ; Tang, Biao 3 ; Kang, Xiamei 1 ; Mueller, Anja 4 ; Kehrenberg, Corinna 4 ; Jia, Chenghao 2 ; Pan, Hang 1 ; Yang, Hua 3 ; Yue, Min 1 ;

作者机构： 1.Zhejiang Univ Coll Anim Sci, Inst Prevent Vet Sci, Dept Vet Med, Hangzhou, Zhejiang, Peoples R China

2.Hainan Inst Zhejiang Univ, Sanya, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China

4.Justus Liebig Univ Giessen, Inst Vet Food Sci, Fac Vet Med, Giessen, Germany

5.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Natl Clin Res Ctr Infect Dis,State Key Lab Diag &, Hangzhou, Peoples R China

6.Zhejiang Prov Key Lab Prevent Vet Med, Hangzhou, Peoples R China

关键词： Salmonella; Antimicrobial Resistance; Persistence; Environmental Stress; Antibiotics Ban; Antibiotic-Free Feed

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：14.224； 五年影响因子：12.984 ）

ISSN： 0304-3894

年卷期： 2022 年 438 卷

页码：

收录情况： SCI

摘要： To counteract the dramatic increase in antibiotic-resistant bacterial pathogens, many countries, including China, have banned the use of antibiotic-supplemented feed for farming animals. However, the exact consequences of this policy have not been systematically evaluated. Therefore, Salmonella isolates from farms that ceased using antibiotics 1-5 years ago were compared with isolates from farms that continue to use antimicrobials as growth promotors. Here, we used whole-genome sequencing combined with in-depth phenotypic assays to investigate the ecology, epidemiology, and persistence of multi-drug resistant (MDR) Salmonella from animal farms during the withdrawal of antibiotic growth promotors. Our results showed that the prevalence of Salmonella was significantly lower in antibiotic-free feed (AFF) farms compared to conventional-feed (CF) farms, even though all isolates obtained from AFF farms were MDR (> 5 classes) and belonged to well-recognized predominant serovars. The additional phylogenomic analysis combined with principal component analysis showed high similarity be-tween the predominant serovars in AFF and CF farms. This result raised questions regarding the environmental persistence capabilities of MDR strain despite AFF policy. To address this question, a representative panel of 20 isolates was subjected to disadvantageous environmental stress assays. These results showed that the predomi-nant serovars in AFF and CF farms were more tolerant to stress conditions than other serovars. Collectively, our findings suggest that AFF helps eliminate only specific MDR serovars, and future guiding policies would benefit by identifying predominant Salmonella clones in problematic farms to determine the use of AFF and additional targeted interventions.

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