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Effect of Resveratrol Supplementation on Intestinal Oxidative Stress, Immunity and Gut Microbiota in Weaned Piglets Challenged with Deoxynivalenol

文献类型： 外文期刊

作者： Qiu, Yueqin 1 ; Nie, Xinzhi 1 ; Yang, Jun 1 ; Wang, Li 1 ; Zhu, Cui 6 ; Yang, Xuefen 1 ; Jiang, Zongyong 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China

2.State Key Lab Livestock & Poultry Breeding, Guangzhou 510640, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou 510640, Peoples R China

4.Guangdong Prov Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

5.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Guangzhou 510640, Peoples R China

6.Foshan Univ, Sch Life Sci & Engn, Foshan 528225, Peoples R China

关键词： deoxynivalenol; intestinal inflammation; gut microbiota; Lactobacillus gasseri; oxidative stress; piglets; resveratrol

期刊名称：ANTIOXIDANTS （ 影响因子：7.675； 五年影响因子：7.886 ）

ISSN：

年卷期： 2022 年 11 卷 9 期

页码：

收录情况： SCI

摘要： (1) Background: Deoxynivalenol (DON) is a general mycotoxin that induces severe intestinal barrier injury in humans and animals. Resveratrol (RES) efficiently exerts anti-inflammatory and antioxidant effects. However, the information regarding RES protecting against DON-induced oxidative stress and intestinal inflammation in piglets is limited. (2) Methods: A total of 64 weaned piglets (Duroc x (Landrace x Yorkshire), 21-d-old, barrow) were randomly allocated to four groups (eight replicate pens per group, each pen containing two piglets) for 28 d. The piglets were fed a control diet (CON) or the CON diet supplemented with 300 mg RES/kg diet (RES group), 3.8 mg DON/kg diet (DON) or both (DON+RES) in a 2 x 2 factorial design. (3) Compared with unsupplemented DON-challenged piglets, RES supplementation in DON-challenged piglets increased ileal villus height and the abundance of ileal SOD1, GCLC and PG1-5 transcripts and Muc2 protein (p < 0.05), while decreasing the mRNA and proteins expression of ileal IL-1 beta, IL-6 and TNF-alpha, and malondialdehyde (MDA) levels in plasma and ileum in DON-challenged piglets (p < 0.05). Moreover, the abundances of class Bacilli, order Lactobacillales, family Lactobacillaceae and species Lactobacillus gasseri were increased in DON-challenged piglets fed a RES-supplemented diet compared with those in DON-challenged piglets(p <= 0.05). (4) Conclusions: our results indicated that RES supplementation in DON-challenged piglets efficiently attenuated intestinal inflammation and oxidative stress and improved gut microbiota, thereby alleviating DON-induced intestinal barrier injury.

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