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The pyran ring isopentene group: an overlooked antimicrobial active group in prenylated flavonoids

文献类型： 外文期刊

作者： Pang, Daorui 1 ; Liao, Sentai 1 ; Zhou, Pengfei 1 ; Liu, Fan 1 ; Zou, Yuxiao 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou, Guangdong, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc, Guangzhou, Guangdong, Peoples R China

关键词： Mulberry root bark; prenylated flavonoids; antibacterial activity; pyran ring isopentane groups; prenyl side-chains

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.488； 五年影响因子：2.51 ）

ISSN： 1478-6419

年卷期：

页码：

收录情况： SCI

摘要： Prenylated flavonoids show antibacterial activity towards Staphylococcus aureus (S. aureus). Previous studies have suggested that the prenyl side-chain is an important active group for antimicrobial activity. However, prenylated flavonoids also often contain a pyran ring isopentene group. Few studies have explored the contribution of the pyran ring isopentene group to antibacterial activity. In this study, the antibacterial activities of structurally related flavonoid compounds from mulberry root bark were studied by detecting the minimum inhibitory concentration (MIC) and colony counting. These flavonoid compounds all exhibited antibacterial activities against S. aureus ATCC6538, S. aureus ATCC25923 and methicillin-resistant S. aureus (MRSA) ATCC43300 with MIC values of 7.3-248.2 mu mol/L, 7.3-330.9 mu mol/L, and 7.3-330.9 mu mol/L, respectively. Structure-activity relationship analyses demonstrated that the pyran ring isopentene group plays an important role in antibacterial activity. Thus, the pyran ring isopentene group is an overlooked antimicrobial active group in prenylated flavonoids.

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