Structure Identification and Evaluation of Chemical Components from the Flos Sophorae Immaturus for Inhibitory Effects against HepG2
文献类型： 外文期刊
作者： Xue, Zhaohui 1 ; Song, Weichen 1 ; Gao, Xin 1 ; Yu, Wancong 2 ; Hou, Xiaonan 1 ; Kou, Xiaohong 1 ;
作者机构： 1.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300350, Peoples R China
2.Tianjin Acad Agr Sci, Tianjin 300381, Peoples R China
关键词： Ras Sophorae Immaturus; Functional components; Structure-activity analysis; Tumor suppressive activity
期刊名称：CURRENT TOPICS IN NUTRACEUTICAL RESEARCH （ 影响因子：0.416； 五年影响因子：0.536 ）
ISSN： 1540-7535
年卷期： 2021 年 19 卷 4 期
页码：
收录情况： SCI
摘要： Flos Sophorae Immaturus, dried buds of Sophora japonica, exhibits multiple pharmacologic activities including anti-inflammatory, antiaging, and antiallergy effects as well as adjunct to standard of care cancer therapy. However, active components responsible for beneficial effects in cancer are not known. In this study, Flos Sophorae Immaturus was obtained by ethanol extraction, and eight components were purified, identified, and tested for HepG2 cell proliferation inhibition potency. The compounds identified to be the most effective inhibitors were campherol > isorhamnetin > quercetin. These data provide theoretical and scientific basis for the further development, utilization, and the promotion of added value of Flos Sophorae Immaturus.
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