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Antibacterial Mechanism of Cinnamaldehyde: Modulation of Biosynthesis of Phosphatidylethanolamine and Phosphatidylglycerol in Staphylococcus aureus and Escherichia coli

文献类型： 外文期刊

作者： Pang, Daorui 1 ; Huang, Zhaoxiang 1 ; Li, Qian 1 ; Wang, Erpei 4 ; Liao, Sentai 1 ; Li, Erna 1 ; Zou, Yuxiao 1 ; Wang, Weifei 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou 510610, Guangdong, Peoples R China

2.Minist Agr & Rural Affairs, Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Funct Foods, Guangzhou 510610, Guangdong, Peoples R China

4.La Jolla Inst Immunol, Ctr Autoimmun & Inflammat, La Jolla, CA 92037 USA

关键词： cinnamaldehyde; glycerophospholipid biosynthesis pathway; parallel reaction monitoring; phosphatidylethanolamine; phosphatidylglycerol

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.895； 五年影响因子：6.048 ）

ISSN： 0021-8561

年卷期： 2021 年 69 卷 45 期

页码：

收录情况： SCI

摘要： Cinnamaldehyde is a natural antimicrobial food preservative. Previous studies have suggested that cinnamaldehyde interacts with the cell membrane, but the molecular targets of cinnamaldehyde action on foodborne pathogens are still unclear. In this study, the structural changes of Staphylococcus aureus and Escherichia coli cells were observed after cinnamaldehyde treatment. Then, quantitative real-time polymerase chain reaction (PCR) and parallel reaction monitoring were used for determining the effects of cinnamaldehyde treatment of these bacteria on the expression of genes and proteins associated with glycerophospholipid biosynthesis. Changes in fatty acids (raw materials for the biosynthesis of glycerophospholipids) and glycerophospholipids in S. aureus and E. coli after cinnamaldehyde treatment were analyzed to confirm the results of gene and protein expression experiments. Cinnamaldehyde regulated the glycerophospholipid biosynthesis pathways of these foodborne pathogens, mainly targeting phosphatidylglycerol and phosphatidylethanolamine, which resulted in the disruption of cell membrane integrity.

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