文献类型： 外文期刊
作者： Dong, Sujie 1 ; Kong, Ning 1 ; Shen, Haiyan 3 ; Li, Youwen 2 ; Qin, Wenzhen 1 ; Zhai, Huanjie 1 ; Zhai, Xueying 1 ; Yang, Xinyu 1 ; Ye, Chenqian 1 ; Ye, Manqing 1 ; Liu, Changlong 1 ; Yu, Lingxue 1 ; Zheng, Hao 1 ; Tong, Wu 1 ; Yu, Hai 1 ; Zhang, Wen 4 ; Tong, Guangzhi 1 ; Shan, Tongling 1 ;
作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R China
2.Tarim Univ, Coll Anim Sci, Xinjiang, Peoples R China
3.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou, Peoples R China
4.Jiangsu Univ, Sch Med, Zhenjiang, Peoples R China
关键词： KLF16; PEDV; TRAF6; IFN; Replication
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）
ISSN： 0378-1135
年卷期： 2022 年 274 卷
页码：
收录情况： SCI
摘要： KLF16, a member of KLFs (Kruppel-like factors), contributes to the progression of a variety of cancer types. There is, however, still uncertain regarding the role of KLF16 in viral replication and the signaling mechanism of type I IFN. It was discovered that KLF16 inhibited the replication of porcine epidemic diarrhea virus (PEDV) through the type I IFN signaling pathway. Besides, it can also be found that the expression of KLF16 was down-regulated after PEDV infection of LLC-PK1 cells. Furthermore, overexpression of KLF16 inhibited the replication of PEDV in Vero cells as well as LLC-PK1 cells, whereas the replication of PEDV was promoted by the knockdown of KLF16. KLF16 up-regulated the expression of interferons (IFNs) via the TRAF6-pTBK1-pIRF3 pathway with the aim of promoting the host antiviral innate immune response. In addition, the obtained findings proved that KLF16 plays a novel role in antiviral action, thereby offering novel possibilities for preventing and controlling PEDV.
- 相关文献
作者其他论文 更多>>
-
Transcriptome analysis reveals various genes involved in the regulation of potato to late blight
作者：Zhang, Weina;Ma, Yifan;Kang, Yichen;Zhang, Ruyan;Wang, Yong;Jiao, Shujuan;Wang, Xingxing;Qin, Shuhao;Chen, Zhongjian;Yang, Xinyu
关键词：Potato; Transcriptome; Late blight; Plant-pathogen interaction; Phenylpropanoid biosynthesis; Tolerance; susceptibility
-
The "crosstalk" between gut microbiota, metabolites and genes in diet-induced hepatic steatosis mice intervened with Cordyceps guangdongensis polysaccharides
作者：Wang, Gangzheng;Xie, Bojun;Yang, Xinyu;Zhong, Guorui;Gao, Liang;Chen, Xiangnv;Lin, Min;Huang, Qiuju;Zhang, Chenghua;Huang, Hao;Li, Taihui;Deng, Wangqiu;Yang, Xinyu;Wang, Ruijuan;Xu, Jianping
关键词：Obesity; Cordyceps guangdongensis polysaccharides; Gut microbiota; Bile acid; Lipid metabolism; Carbohydrate metabolism
-
Display of porcine epidemic diarrhea virus spike protein B-cell linear epitope on Lactobacillus mucosae G01 S-layer surface induce a robust immunogenicity in mice
作者：Zhang, Bin;Liu, Zhicheng;Wuri, Nile;Geri, Letu;Zhang, Bin;Gou, Hongchao;Shen, Haiyan;Zhang, Chunhong;Liu, Zhicheng;Wuri, Nile;Nie, Jingjing;Qu, Yunzhi;Zhang, Jianfeng
关键词：PEDV; Epitope; SLP; L. mucosae G01; Probiotics surface
-
A novel linear displacement isothermal amplification with strand displacement probes (LDIA-SD) in a pocket-size device for point-of-care testing of infectious diseases
作者：Gou, Hongchao;Shen, Haiyan;Zhang, Chunhong;Liao, Ming;Lin, Qijie;Jia, Kaiyuan;Liang, Yucen;Peng, Junhao;Qu, Xiaoyun;Zhang, Jianmin;Liao, Ming;Li, Yanbin;Lin, Jianhan;Zhang, Jianmin;Liao, Ming
关键词：Nucleic Acid Amplification; Isothermal amplification; Point -of -care testing (POCT); Linear displacement isothermal amplification; (LDIA); Infectious diseases
-
Fangchinoline inhibits the PEDV replication in intestinal epithelial cells via autophagic flux suppression
作者：Zhang, Weixiao;Wang, Menglu;Fan, Xuelei;Wang, Songqi;Li, Yugu;Zhang, Jianmin;Zhang, Weixiao;Shen, Haiyan;Wang, Menglu;Fan, Xuelei;Wang, Songqi;Wuri, Nile;Zhang, Bin;He, Haiyan;Zhang, Chunhong;Liu, Zhicheng;Liao, Ming;Zhang, Jianfeng;Shen, Haiyan;Zhang, Chunhong;Liu, Zhicheng;Liao, Ming;Zhang, Jianfeng;Wuri, Nile;Zhang, Bin;He, Haiyan
关键词：porcine epidemic diarrhea virus; fangchinoline; antiviral agent; autophagy; replication
-
Genomic Characterization of Salmonella enterica serovar Weltevreden Associated with Human Diarrhea
作者：Zhang, Jianmin;Chen, Kaifeng;Zhan, Zeqiang;Feng, Saixiang;Qu, Xiaoyun;Liao, Ming;Zhang, Jianmin;Chen, Kaifeng;Zhan, Zeqiang;Feng, Saixiang;Qu, Xiaoyun;Liao, Ming;Zhang, Jianmin;Chen, Kaifeng;Zhan, Zeqiang;Feng, Saixiang;Qu, Xiaoyun;Liao, Ming;Zhang, Jianmin;Chen, Kaifeng;Zhan, Zeqiang;Feng, Saixiang;Qu, Xiaoyun;Liao, Ming;Peng, Zhong;Wang, Xiangru;Chen, Huanchun;Wu, Bin;Peng, Zhong;Wang, Xiangru;Chen, Huanchun;Wu, Bin;Peng, Zhong;Shen, Haiyan;Gou, Hongchao;Liao, Ming;Ziemann, Mark;Layton, Daniel S.;Xu, Xuebin
关键词：IncFII(S) type plasmid; ST365; Salmonella Weltevreden; human diarrhea; whole-genome sequence and phylogenetic analysis
-
Lactate is useful for the efficient replication of porcine epidemic diarrhea virus in cell culture
作者：Wuri, Nile;Gou, Hongchao;Zhang, Bin;Wang, Menglu;Wang, Songqi;Zhang, Weixiao;He, Haiyan;Fan, Xuelei;Zhang, Chunhong;Liu, Zhicheng;Shen, Haiyan;Zhang, Jianfeng;Wuri, Nile;Zhang, Bin;He, Haiyan;Geri, Letu;Gou, Hongchao;Zhang, Chunhong;Liu, Zhicheng;Shen, Haiyan;Zhang, Jianfeng;Wang, Menglu;Wang, Songqi;Zhang, Weixiao;Fan, Xuelei
关键词：porcine epidemic diarrhea virus; metabolites; glucose; glutamine; lactate
