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The "crosstalk" between gut microbiota, metabolites and genes in diet-induced hepatic steatosis mice intervened with Cordyceps guangdongensis polysaccharides

文献类型： 外文期刊

作者： Wang, Gangzheng 1 ; Xie, Bojun 1 ; Yang, Xinyu 1 ; Wang, Ruijuan 3 ; Zhong, Guorui 1 ; Gao, Liang 1 ; Chen, Xiangnv 1 ; Lin, Min 1 ; Huang, Qiuju 1 ; Zhang, Chenghua 1 ; Huang, Hao 1 ; Li, Taihui 1 ; Xu, Jianping 4 ; Deng, Wangqiu 1 ;

作者机构： 1.Guangdong Acad Sci, Inst Microbiol, Guangdong Prov Key Lab Microbial Culture Collect &, State Key Lab Appl Microbiol Southern China, Guangzhou, Peoples R China

2.Zhongkai Univ Agr & Engn, Coll Agr & Biol, Guangzhou 510225, Peoples R China

3.Guangdong Acad Agr Sci, Vegetable Res Inst, Guangdong Key Lab New Technol Res Vegetables, Guangzhou 510640, Peoples R China

4.McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada

关键词： Obesity; Cordyceps guangdongensis polysaccharides; Gut microbiota; Bile acid; Lipid metabolism; Carbohydrate metabolism

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：7.7； 五年影响因子：7.7 ）

ISSN： 0141-8130

年卷期： 2024 年 277 卷

页码：

收录情况： SCI

摘要： Cordyceps guangdongensis, , a novel edible mushroom in China, has shown many positive health effects. In this study, we extracted the C. guangdongensis polysaccharides (CGP) from the fruiting bodies, and investigated the mechanism for CGP improved high-fat diet-induced (HFDI) metabolic diseases. We found that CGP notably reduced fat mass, improved blood lipid levels and hepatic damage, and restored the gut microbiota dysbiosis induced by high-fat diet (HFD). Metabolome analyses showed that CGP changed the composition of bile acids, and regulated HFDI metabolic disorder in hepatic tissue. Transcriptome comparison showed that the improvement of hepatic steatosis for CGP was mainly related to lipid and carbohydrate metabolism. Association analysis result revealed that Odoribacter, , Bifidobacterium and Bi. pseudolongum were negatively correlated to fat and blood lipid indicators, and were significantly associated with genes and metabolites related to carbohydrate and lipid metabolism. Collectively, these results indicate that CGP may be a promising supplement for the treatment of obesity and related metabolic diseases.

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