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Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos

文献类型： 外文期刊

作者： Tanaka, Yasuaki 1 ; Fujiwara, Mari 1 ; Shindo, Asako 1 ; Yin, Guojun 3 ; Kitazawa, Takio 1 ; Teraoka, Hiroki 1 ;

作者机构： 1.Rakuno Gakuen Univ, Sch Vet Med, Ebetsu, Hokkaido 0694501, Japan

2.Nagoya Univ, Div Biol Sci, Dept Mol Biol, Grad Sch Sci, Nagoya, Aichi, Japan

3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi 214081, Peoples R China

关键词： Catecholamine;Motor movement;Non-coplanar PCB;PBDE;Zebrafish

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2018 年 193 卷

页码：

收录情况： SCI

摘要： Contamination with polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the environment is a major concern due to their persistent bioaccumulative toxicity that can disturb neurobehavioral functions including movements. Recently, it was reported that some PBDE including BDE-47 stimulates locomotor activities of zebrafish embryos by unknown mechanism. In this study, motor movements of the zebrafish embryo were used as a model system to evaluate the neuronal toxicity of a non-coplanar PCB-dominant mixture (Aroclor 1254) and BDE-47. Both organohalogens increased tail shaking and rotation of embryos in a concentration-dependent manner. Chemical inhibition and gene knock-down of tyrosine hydroxylase and vesicular monoamine transporter 2 (VMAT2) also induced hyperactivities. Hyperactivities induced by these treatments were all inhibited by supplementation of L-tyrosine and L-dopa, precursors of dopamine synthesis. Both organohalogens reduced dopamine contents and increased the 3,4-dihydroxyphenylacetic acid (DOPAC)/dopamine ratio in whole embryos. The results suggest that functional inhibition of dopaminergic neurons is involved in hyper activities of zebrafish embryos caused by Aroclor 1254 and BDE-47. (C) 2017 Elsevier Ltd. All rights reserved.

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