Influence of epistatic segregation distortion loci on genetic marker linkages in Japanese flounder
文献类型: 外文期刊
作者: Zhao, Jingli 1 ; Han, Dandan 2 ; Shi, Kuntao 3 ; Wang, Li 3 ; Gao, Jin 1 ; Yang, Runqing 1 ;
作者机构: 1.Chinese Acad Fishery Sci, Res Ctr Aquat Biotechnol, Minist Agr, Key Lab Aquat Genom, Beijing 100141, Peoples R China
2.Heilongjiang Vocat Coll Nationalities, Dept Biol Sci & Technol, Harbin 150066, Heilongjiang, Peoples R China
3.Shandong Weihai Inst Ocean & Aquaculture, Div Comprehens Aquaculture, Weihai 264200, Peoples R China
关键词: Distorted segregation;Genetic linkage map;SDL;Epistasis;Japanese flounder
期刊名称:GENOMICS ( 影响因子:5.736; 五年影响因子:4.939 )
ISSN: 0888-7543
年卷期: 2018 年 110 卷 1 期
页码:
收录情况: SCI
摘要: For genetic linkage analysis of Japanese flounder, 160 doubled haploids (DH) were artificially produced using mitotic gynogenesis and were genotyped for 458 simple sequence repeat (SSR) markers, 101 of which show distortional segregation. The genetic linkage map was constructed by modifying recombination fractions between the distorted markers. Between the corrected and uncorrected genetic maps, there were considerable differences in genetic distance, but not in relative locations among markers. Using a liability model, a segregation distortion locus (SDL), with an additive genetic effect of 1.772, was mapped between markers BDHYP387 and Poli56TUF of chromosome 24 in the corrected genetic map. Additionally, six pairs of epistatic SDLs were identified on chromosomes 1, 5, 8, 9, 23, and 24. Changes in genetic distances between markers did not occur on chromosome regions with main effect SDLs. However, most chromosome regions where genetic distances changed covered the detected epistatic SDLs. This study concluded that epistatic SDLs decrease linkages between markers and lengthen genetic distances in Japanese flounder. This finding has been partially validated in other DH populations derived from three female Japanese flounders.
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