Identification of crucial factors involved in Cynoglossus semilaevis sexual size dimorphism by GWAS and demonstration of zbed1 regulatory network by DAP-seq
文献类型： 外文期刊
作者： Wang, Na 1 ; Gao, Jin 2 ; Liu, Yang 1 ; Shi, Rui 1 ; Chen, Songlin 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao Natl Lab Marine Sci & Technol, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
2.Hainan Acad Ocean & Fisheries Sci, Haikou 570203, Hainan, Peoples R China
3.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China
4.Minist Agr, Key Lab Sustainable Dev Marine Fisheries, Qingdao 266071, Peoples R China
关键词： Sexual size dimorphism; Cynoglossus semilaevis; GWAS; ZBED1; DREF; DAP-seq
期刊名称：GENOMICS （ 影响因子：4.31； 五年影响因子：4.38 ）
ISSN： 0888-7543
年卷期： 2022 年 114 卷 3 期
页码：
收录情况： SCI
摘要： Sexual size dimorphism (SSD), whereby females and males exhibit different body sizes, are widely documented in animals. To explore crucial regulators implicated in female-biased SSD of Chinese tongue sole (Cynoglossus semilaevis), GWAS was conducted on 350 females and 59 males. Twenty SNPs and 25 genes including zbed1, nsd3, cdc45, klhl29, and smad4 with-log(p) > 7 were screened, mainly mapping to sex chromosome. The chromosome W-linked gene zbed1 attracted particular attention because it is a master key for cell proliferation. Thus, the regulatory network of zbed1 in C. semilaevis was explored by DAP-seq and 1352 peaks were discovered in the female brain. Moreover, zbed1 potentially regulated hippo signaling pathway, cell cycle, translation, and PI3kAkt signaling pathway in C. semilaevis. These findings identify crucial SNPs and genes associated with female biased SSD in C. semilaevis, also provide the first genome-wide survey for the zbed1 regulatory network in fish species.
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