Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration
文献类型: 外文期刊
作者: Chang Zhiqiang 1 ; Liu Fei 1 ; Lian Chun'ang 1 ; Zhai Qianqian 1 ; Li Jian 1 ;
作者机构: 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr, Key Lab Sustainable Dev Marine Fisheries, Qingdao 266071, Peoples R China
2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China
关键词: pharmacokinetics;acetylation;sulfamethoxazole;turbot
期刊名称:CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY ( 影响因子:1.068; 五年影响因子:0.983 )
ISSN: 0254-4059
年卷期: 2016 年 34 卷 4 期
页码:
收录情况: SCI
摘要: The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18 degrees C were investigated. Either SMX (parent drug) or its acetylized metabolite, N-4-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two-and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h.kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.
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