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Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration

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文献类型：外文期刊

作者： Chang Zhiqiang ¹ ; Liu Fei ¹ ; Lian Chun'ang ¹ ; Zhai Qianqian ¹ ; Li Jian ¹ ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr, Key Lab Sustainable Dev Marine Fisheries, Qingdao 266071, Peoples R China

2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

关键词： pharmacokinetics;acetylation;sulfamethoxazole;turbot

期刊名称：CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY （影响因子：1.068；五年影响因子：0.983 ）

ISSN： 0254-4059

年卷期： 2016 年 34 卷 4 期

页码：

收录情况： SCI

摘要： The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18 degrees C were investigated. Either SMX (parent drug) or its acetylized metabolite, N-4-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two-and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h.kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.

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