您好,欢迎访问中国水产科学研究院 机构知识库!

Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration

文献类型: 外文期刊

作者: Chang Zhiqiang 1 ; Liu Fei 1 ; Lian Chun'ang 1 ; Zhai Qianqian 1 ; Li Jian 1 ;

作者机构: 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr, Key Lab Sustainable Dev Marine Fisheries, Qingdao 266071, Peoples R China

2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

关键词: pharmacokinetics;acetylation;sulfamethoxazole;turbot

期刊名称:CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY ( 影响因子:1.068; 五年影响因子:0.983 )

ISSN: 0254-4059

年卷期: 2016 年 34 卷 4 期

页码:

收录情况: SCI

摘要: The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18 degrees C were investigated. Either SMX (parent drug) or its acetylized metabolite, N-4-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two-and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h.kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.

  • 相关文献

[1]The effect of vaccinating turbot broodstocks on the maternal immunity transfer to offspring immunity. Han Mingming,Meng Zhen,Lei Jilin,Han Mingming,Ding FuHong,Meng Zhen.

[2]Characterization and expression profiling of NOD-like receptor C3 (NLRC3) in mucosal tissues of turbot (Scophthalmus maximus L.) following bacterial challenge. Hou, Zhumei,Gao, Chengbin,Song, Lin,Song, Huanhuan,Wang, Yu,Li, Chao,Ye, Zhi,Zhang, Dongdong,Tan, Fenghua,Su, Baofeng,Su, Baofeng.

[3]The effect of ultrafiltered fish protein hydrolysate levels on the liver and muscle metabolic profile of juvenile turbot (Scophthalmus maximus L.) by H-1 NMR-based metabolomics studies. Wei, Yuliang,Liang, Mengqing,Zheng, Keke,Xu, Houguo,Wei, Yuliang,Mai, Kangsen,Wei, Yuliang,Mai, Kangsen.

[4]Effect of dietary vitamin E on the growth performance and nonspecific immunity in sub-adult turbot (Scophthalmus maximus). Jia, Yudong,Hu, Peng,Meng, Zhen,Lei, Jilin,Niu, Huaxin.

[5]Isolation and characterization of microsatellite markers for turbot (Scophthalmus maximus) by screening SSR-enriched library. Gu, Ying,Zhao, Yingying,Lu, Cuiyun,Sun, Xiaowen,Gu, Ying,Zhao, Yingying,Liu, Yongxin.

[6]Molecular cloning and expression analysis of a hepcidin antimicrobial peptide gene from turbot (Scophthalmus maximus). Chen, Song-Lin,Li, Wei,Meng, Liang,Sha, Zhen-Xia,Wang, Zhi-Jian,Ren, Guo-Cheng. 2007

[7]Specific MHC class II B alleles associated with resistance to Edwardsiella tarda in turbot, Psetta maxima (L.). Xu, J-Y,Chen, S-L,Ding, H.,Xu, J-Y. 2009

[8]Isolation and analysis of microsatellites in the genome of turbot (Scophthalmus maximus L.). Ruan, Xiaohong,Hu, Jingjie,Ruan, Xiaohong,Wang, Weiji,Kong, Jie. 2011

[9]Cloning, characterization, and expression of a novel member of proteasomal subunits gene in turbot, Scophthalmus maximus. Zhang Bo,Song Wenping,Zheng Debin,Ma Chao,Xiao Guangxia,Wang Xianli. 2015

[10]Estimation of genetic parameters for growth trait of turbot using Bayesian and REML approaches. Guan, Jiantao,Guan, Jiantao,Wang, Weiji,Hu, Yulong,Wang, Mosang,Tian, Tao,Kong, Jie,Wang, Mosang,Tian, Tao. 2017

[11]Molecular identification and expression analysis of the natural killer cell enhancing factor (NKEF) gene from turbot (Scophthalmus maximus). Chen, Ying,Zhang, Yu-Xi,Fan, Ting-Jun,Meng, Liang,Ren, Guo-cheng,Chen, Song-Lin. 2006

[12]Development and characterization of a continuous embryonic cell line from turbot (Scophthalmus maximus). Chen, SL,Ren, GC,Sha, ZX,Hong, YH. 2005

[13]Study on the immune enhancement of different immunoadjuvants used in the pentavalent vaccine for turbots. Zhang Zheng,Wang Yingeng,Wang Qingyin,Deng Nannan,Liao Meijie,Li Bin,Wang Lan,Zhang Zheng,Qu Jiangbo. 2012

[14]Isolation and characterization of 45 polymorphic microsatellite loci of turbot (Scophthalmus maximus) and cross-species amplification. Hou Shiying,Ma Aijun,Wang Xin'an,Huang Zhihui,Xue Baogui,Qu Jiangbo,Hou Shiying,Qu Jiangbo. 2011

[15]Cloning, characterization and expression analysis of a cold shock domain family member YB-1 in turbot Scophthalmus maximus. Zhang, Yu-Xi,Zhang, Bo,Chen, Song-Lin,Wang, Xian-Li,Yang, Chang-Geng. 2012

[16]An estimation of genetic parameters of growth traits in juvenile turbot (Scophthalmus maximus L.) using parental molecular relatedness. Hu Yulong,Guan Jiantao,Ma Yu,Kong Jie,Wang Weiji,Guan Jiantao. 2016

[17]Iron-metabolic function and potential antibacterial role of Hepcidin and its correlated genes (Ferroportin 1 and Transferrin Receptor) in Turbot (Scophthalmus maximus). Yang, Chang-Geng,Liu, Shan-Shan,Sun, Bing,Wang, Na,Chen, Song-Lin,Yang, Chang-Geng,Sun, Bing,Wang, Xian-Li. 2013

[18]Rapid diagnosis of turbot reddish body iridovirus in turbot using the loop-mediated isothermal amplification method. Zhang, Qingli,Shi, Chenyin,Huang, Jie,Jia, Kuntong,Chen, Xinhua,Liu, Hong. 2009

[19]The immune response of turbot, Scophthalmus maximus (L.), skin to high water temperature. Huang, Z-H,Ma, A-J,Wang, X-A. 2011

[20]Inbreeding evaluation using microsatellite and its effect on growth traits in turbot, Scophthalmus maximus. Lyu, Ding,Wu, Huanhuan,Hu, Yulong,Wang, Weiji,Lyu, Ding,Wu, Huanhuan,Hu, Yulong,Wang, Weiji. 2018

作者其他论文 更多>>