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Assessment and Comparison of in vitro Immunoregulatory Activity of Three Astaxanthin Stereoisomers

文献类型: 外文期刊

作者: Sun Weihong 1 ; Xing Lihong 1 ; Lin Hong 2 ; Leng Kailiang 1 ; Zhai Yuxiu 1 ; Liu Xiaofang 1 ;

作者机构: 1.Chinese Acad Fishery Sci, Yellow Sea Fishery Res Inst, Qingdao 266071, Peoples R China

2.Ocean Univ China, Coll Food Sci & Engn, Qingdao 266003, Peoples R China

关键词: all-trans-astaxanthin;stereoisomer;immunity

期刊名称:JOURNAL OF OCEAN UNIVERSITY OF CHINA ( 影响因子:0.913; 五年影响因子:1.012 )

ISSN: 1672-5182

年卷期: 2016 年 15 卷 2 期

页码:

收录情况: SCI

摘要: In recent years, the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied. It was reported that all-trans astaxanthin might exist as three stereoisomers, and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products. However, the different biological effects of various all-trans stereoisomers still remain unclear. In the present study, we evaluated the bioactivity of three astaxanthin stereoisomers, (3S,3'S)-trans-, (3R,3'R)-transand meso-trans-astaxanthin, in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells (PECs) systems. After the treatment with three astaxanthin stereoisomers (20 mu mol L-1), the lymphocyte proliferation capacity, neutral red phagocytosis of PECs and natural killer (NK) cell cytotoxic activity were comparatively assessed. The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation, phagocytic capacity of PECs, and cytotoxic activity of NK cells. Moreover, the (3S,3'S)-trans-astaxanthin exhibited a much higher response than others.

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