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LDH nanoparticle adjuvant subunit vaccine induces an effective immune response for porcine epidemic diarrhea virus

文献类型： 外文期刊

作者： Shi, Danyi 1 ; Fan, Baochao 1 ; Sun, Bing 3 ; Zhou, Jinzhu 1 ; Zhao, Yongxiang 1 ; Guo, Rongli 1 ; Ma, Zengjun 2 ; Song, Tao 2 ; Fan, Huiying 8 ; Li, Jizong 1 ; Li, Li 1 ; Li, Bin 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Jiangsu Key Lab Food Qual & Safety, Key Lab Vet Biol Engn & Technol,Minist Agr, Inst Vet Med,State Key Lab Cultivat Base,Minist S, Nanjing 210014, Jiangsu, Peoples R China

2.Hebei Normal Univ Sci & Technol, Coll Anim Sci & Technol, Qinhuangdao, Hebei, Peoples R China

3.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia

4.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Jiangsu Key Lab Zoonosis, Yangzhou 225009, Jiangsu, Peoples R China

5.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China

6.Nanjing Agr Univ, 5Coll Vet Med, 1 Wei Gang, Nanjing 210095, Peoples R China

7.Jiangsu Univ, Sch Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China

8.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China

关键词： Spike gene; Subunit vaccines; LDH nanoparticle Adjuvant; PEDV

期刊名称：VIROLOGY （ 影响因子：3.513； 五年影响因子：3.479 ）

ISSN： 0042-6822

年卷期： 2022 年 565 卷

页码：

收录情况： SCI

摘要： Porcine Epidemic Diarrhea (PED) is a highly contagious intestinal disease which mostly caused by Porcine Epidemic Diarrhea Virus (PEDV). The PED has caused huge economic losses to the pig industry all over the world and a valid PEDV vaccine is needed to prevent the infection. In this study, we constructed expression plasmid based on the spike (S) gene of the epidemic PEDV strain. The recombinant eukaryotic S (Se) and prokaryotic S (Sp) subunit proteins were expressed and purified as vaccine antigens. We designed a new subunit vaccine based on S proteins, adjuvanted with layered double hydroxide (LDH). The results indicated that the LDH adjuvanted subunit vaccines induced a better immune effect in terms of antibody level and cellular immune response. In conclusion, this study showed a new design of a PEDV subunit vaccine with nanotechnology and demonstrated the potential for its clinical application.

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