文献类型： 外文期刊

作者： Han, Ziyi ¹ ; Zhao, Lingyang ¹ ; Hu, Qilin ¹ ; Hung, Ifen ² ; Liu, Chunxue ² ; Liu, Shijie ⁴ ; Mei, Xuehua ⁴ ; Zeng, Xiu ⁴ ; Bin, Peng ¹ ; Wang, Junhong ¹ ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangzhou 510642, Peoples R China

2.Anyou Biotechnol Grp Co LTD, Taicang, Peoples R China

3.Centree Biotech Wuhan Co LTD, Joint Lab Funct Nutr & Anim Hlth, Wuhan, Peoples R China

4.Natl Ctr Technol Innovat Pigs, Chongqing, Peoples R China

关键词： Gut microbiota; amino acid metabolism; microbial homeostasis

期刊名称：GUT MICROBES （ 影响因子：11.0； 五年影响因子：13.4 ）

ISSN： 1949-0976

年卷期： 2025 年 17 卷 1 期

页码：

收录情况： SCI

摘要： The gut microbiota plays a crucial role in regulating host amino acid availability and metabolism through complex interactions with the host metabolic processes. This review summarizes three main mechanisms through which the microbiota influences host amino acid homeostasis. Firstly, gut microbiota actively competes for luminal amino acids derived from the diet and concurrently contributes to the host's amino acid pool through de novo biosynthesis. Secondly, they modulate host intestinal hydrolases and amino acid transporters, thereby fine-tuning amino acid absorption and systemic bioavailability. Thirdly, microbially secreted factors, including diverse metabolites and extracellular vesicles, reprogram host amino acid metabolic pathways. The inherent inter-individual variations in microbial composition and metabolic capacity highlight the necessity of personalized therapeutic strategies targeting the microbiota. By summarizing current findings, this review aims to provide a deeper understanding of this dynamic interplay and to identify promising avenues for future investigations in the field.