文献类型： 外文期刊
作者： Wang, Youxia 1 ; Zhang, Xinmei 1 ; Hung, Ifen 2 ; Liu, Chunxue 2 ; Ren, Wenkai 1 ; Ge, Liangpeng 4 ; Wang, Hao 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China
2.Anyou Biotechnol Grp Co Ltd, Taicang, Peoples R China
3.Centree Biotech Wuhan Co LTD, Joint Lab Funct Nutr & Anim Hlth, Wuhan, Peoples R China
4.Chongqing Acad Anim Sci, Natl Ctr Technol Innovat Pigs, Key Lab Pig Ind Sci, Minist Agr, Chongqing, Peoples R China
5.Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang, Henan, Peoples R China
期刊名称：RESEARCH （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 2096-5168
年卷期： 2024 年 7 卷
页码：
收录情况： SCI
摘要： The prevalence of food allergies is increasing dramatically and causing serious public health concerns. Notably, melatonin metabolism imbalance in patients with food allergies; however, the role of melatonin in food allergies remains unclear. Here, we demonstrated that melatonin suppresses food allergy responses and reprograms the gut microbiota of food-allergic mice, while melatonin aggravates food allergy during gut microbiota depletion. Mechanistically, melatonin boosts the degranulation of mast cells by up-regulating the expression of membrane high-affinity immunoglobulin E (IgE) receptor (Fc epsilon RI). Melatonin increases the mRNA expression of Rabenosyn-5 (a component of factors for endosome recycling and Rab interactions) through melatonin receptor 2 (MT2)-extracellular signal-regulated kinase (ERK) signaling, thereby driving the recycling of Fc epsilon RI and elevating the abundance of membrane Fc epsilon RI. Likewise, the inhibition of MT2 attenuates melatonin-induced food allergy in mice with gut microbiota depletion. Collectively, our finding provides insights into the pathogenesis of food allergies and provides a potential therapeutic target for the prevention and treatment of food allergies.
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